Changes in leukocyte profile and C-reactive protein concentration in overweight and obese adolescents after reduction of body weight.
adolescents
insulin resistance
leukocyte profile
low-grade inflammatory state
Journal
Central-European journal of immunology
ISSN: 1426-3912
Titre abrégé: Cent Eur J Immunol
Pays: Poland
ID NLM: 9702239
Informations de publication
Date de publication:
2019
2019
Historique:
received:
13
11
2018
accepted:
25
01
2019
entrez:
25
12
2019
pubmed:
25
12
2019
medline:
25
12
2019
Statut:
ppublish
Résumé
To assess the changes in the leukocyte profile and C-reactive protein (CRP) concentration in adolescents with excess fat mass after 6-12 months of dietary intervention. The retrospective study included 99 overweight and obese adolescents, aged from 10.0 to 17.5 years, 82 of whom were re-hospitalized 6 to 12 months after dietary counseling. The control group consisted of 42 normal weight peers. Anthropometric measurements and laboratory tests were performed, homeostasis model assessment - insulin resistance (HOMA-IR) and triglycerides/high-density lipoprotein cholesterol (TG/HDL-C) ratio were calculated. Obese and overweight adolescents had higher white blood cells (WBC), neutrophil, monocyte counts and CRP concentration. In the backward stepwise regression analysis, body mass index standard deviation score (BMI SDS) and fasting insulin concentration were independent predictors of WBC and neutrophil counts at the baseline. At the follow-up visit in 45 (54.8%) children, who had lost weight, decreases in WBC, neutrophil and monocyte counts and CRP, fasting insulin, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) concentrations were observed. Changes in WBC and neutrophil counts were dependent on changes in HOMA-IR and TG/HDL ratio. Changes in HOMA-IR had a significant impact on changes in the monocyte count. Adipose tissue promotes systemic inflammation and its intensity depends on the degree of obesity and insulin resistance. This state is reversible. Changes in HOMA-IR were independent predictors of changes in WBC, neutrophil and monocyte counts after reduction of body weight.
Identifiants
pubmed: 31871419
doi: 10.5114/ceji.2019.89608
pii: 89608
pmc: PMC6925564
doi:
Types de publication
Journal Article
Langues
eng
Pagination
307-315Informations de copyright
Copyright: © 2019 Polish Society of Experimental and Clinical Immunology.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Pediatrics. 2005 Apr;115(4):e500-3
pubmed: 15741351
Tex Heart Inst J. 2013;40(1):17-29
pubmed: 23467296
Open Biochem J. 2010 Jun 10;4:72-6
pubmed: 20676221
Obes Facts. 2015;8(1):1-16
pubmed: 25765160
Am J Clin Nutr. 1999 Jun;69(6):1130-4
pubmed: 10357730
J Pediatr. 2005 Mar;146(3):342-8
pubmed: 15756217
Nutr Metab Cardiovasc Dis. 2016 Jun;26(6):502-9
pubmed: 27048715
Eur J Clin Nutr. 1990 Jan;44(1):45-60
pubmed: 2354692
Rev Paul Pediatr. 2014 Dec;32(4):351-9
pubmed: 25510999
Invest Clin. 2016 Jun;57(2):120-130
pubmed: 28429893
Nutr Metab Cardiovasc Dis. 2017 May;27(5):456-461
pubmed: 28428029
World Health Organ Tech Rep Ser. 1995;854:1-452
pubmed: 8594834
Obes Rev. 2001 May;2(2):131-40
pubmed: 12119664
Int J Obes (Lond). 2008 Dec;32 Suppl 6:S11-8
pubmed: 19079275
Am J Physiol Heart Circ Physiol. 2000 Dec;279(6):H2954-60
pubmed: 11087252
Int J Obes (Lond). 2006 Jun;30(6):906-11
pubmed: 16418751
Mediators Inflamm. 2010;2010:null
pubmed: 20706689
Int J Pediatr Otorhinolaryngol. 2017 Jul;98:85-90
pubmed: 28583511
Arch Med Sci. 2017 Jun;13(4):851-863
pubmed: 28721154
Nutr Metab Cardiovasc Dis. 2010 Mar;20(3):165-72
pubmed: 19616924
Hum Biol. 1988 Oct;60(5):709-23
pubmed: 3224965
Circulation. 2007 Jul 17;116(3):344-57
pubmed: 17592077
Ann Intern Med. 2003 Nov 18;139(10):802-9
pubmed: 14623617
J Am Coll Cardiol. 2005 May 17;45(10):1563-9
pubmed: 15893167
ISRN Inflamm. 2013 Dec 22;2013:139239
pubmed: 24455420
J Clin Endocrinol Metab. 2004 Jun;89(6):2526-39
pubmed: 15181020
Pediatrics. 2001 Jan;107(1):E13
pubmed: 11134477
Pediatr Int. 2009 Feb;51(1):14-8
pubmed: 19371272
PLoS One. 2010 Oct 18;5(10):e13405
pubmed: 20976133
Acta Diabetol. 2010 Mar;47(1):65-71
pubmed: 19238313
J Pediatr. 2002 Sep;141(3):415-20
pubmed: 12219065