Quantitative electrodiagnostic patterns of damage and recovery after spinal cord injury: a pilot study.
Electromyography - EMG
Health care
Journal
Spinal cord series and cases
ISSN: 2058-6124
Titre abrégé: Spinal Cord Ser Cases
Pays: England
ID NLM: 101680856
Informations de publication
Date de publication:
2019
2019
Historique:
received:
30
08
2019
revised:
16
11
2019
accepted:
18
11
2019
entrez:
25
12
2019
pubmed:
25
12
2019
medline:
20
9
2020
Statut:
epublish
Résumé
Prospective observational pilot study. To compare quantitative electromyographic (EMG), imaging and strength data at two time points in individuals with cervical spinal cord injury (SCI). SCI center, Veterans Affairs Health Care System, Palo Alto, California, USA. Subjects without suspected peripheral nerve injury were recruited within 3 months of injury. Needle EMG examination was performed in myotomes above, at, and below the SCI level around 11- and 12-months post injury. EMG data were decomposed using custom software into constituent motor unit trains and each distinct motor unit was analyzed for firing rate and amplitude. Strength measurements were made with dynamometry and according to the International Standard of Neurologic Classification of SCI (ISNCSCI). Cervical magnetic resonance images (MRI) were evaluated by two neuroradiologists for gray and white matter damage around the SCI. Here, we compare the EMG, strength, and imaging findings of the one of the four participants who completed both 3- and 12-month EMG evaluations. There was an increase in force generation in all muscles tested at 1 year. Localized findings of very fast firing motor units helped localize spinal cord damage and revealed gray matter damage in spinal segments where MRI was normal. Meanwhile, improvement in strength over time corresponded with different electrophysiologic patterns. Electromyographic decomposition at two time points provides valuable information about localization of spinal cord damage, integrity of motor neuron pools and may provide a unique understanding of neural recovery mechanisms.
Identifiants
pubmed: 31871766
doi: 10.1038/s41394-019-0246-0
pii: 246
pmc: PMC6908655
doi:
Types de publication
Case Reports
Journal Article
Observational Study
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
101Subventions
Organisme : U.S. Department of Defense (DOD)
ID : SC130314
Informations de copyright
© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019.
Déclaration de conflit d'intérêts
Conflict of interestThe authors declare that they have no conflict of interest.
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