Effects of dietary nitrate and folate supplementation on blood pressure in hypertensive Tanzanians: Design and baseline characteristics of a feasibility trial.
Dietary nitrate
Folate supplementation
Hypertension
Sub Saharan Africa
Journal
Contemporary clinical trials communications
ISSN: 2451-8654
Titre abrégé: Contemp Clin Trials Commun
Pays: Netherlands
ID NLM: 101671157
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
08
05
2019
revised:
09
10
2019
accepted:
11
10
2019
entrez:
25
12
2019
pubmed:
25
12
2019
medline:
25
12
2019
Statut:
epublish
Résumé
The burden of hypertension in Sub-Saharan African countries is rising. Low-cost and effective interventions are needed to mitigate these alarming trends. No evidence is available on the use of dietary nitrate for treating hypertension in African populations. The objectives of this study are to assess the feasibility and efficacy of using beetroot and folate as a combined dietary intervention to treat Tanzanian adults with pre- and mild to moderate hypertension. This was a three-arm double-blind, placebo-controlled, parallel randomised clinical trial conducted within the Hai Demographic Surveillance Site in the Kilimanjaro region in Tanzania. 48 participants were randomised to one of three groups for a 60-day intervention period. Group 1: Combined dietary intervention (beetroot juice and folate), Group 2: Single dietary intervention (beetroot juice and placebo capsule), and Group 3: Control group (placebo beetroot juice and placebo capsule). The primary outcome of the trial was to evaluate the feasibility of the study in a low-income setting. Trial assessments included resting clinic and ambulatory 24-hr blood pressure measurements, lifestyle and dietary questionnaires and collection of biological samples. Our cohort included 8 (16.7%) males and 40 (83.3%) females with mean age 60.7 years (SD 6.5). The mean (SD) BMI, clinic systolic blood pressure and ambulatory systolic blood pressure at baseline were 27.6 kg/m ISRCTN67978523.
Identifiants
pubmed: 31872153
doi: 10.1016/j.conctc.2019.100472
pii: S2451-8654(19)30234-0
pii: 100472
pmc: PMC6915790
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100472Subventions
Organisme : Medical Research Council
ID : MC_PC_16054
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N007921/1
Pays : United Kingdom
Informations de copyright
© 2019 The Author(s).
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
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