Quantification of myocardial

Bone scintigraphy CZT SPECT Cardiac amyloidosis Planar imaging

Journal

EJNMMI research
ISSN: 2191-219X
Titre abrégé: EJNMMI Res
Pays: Germany
ID NLM: 101560946

Informations de publication

Date de publication:
23 Dec 2019
Historique:
received: 02 09 2019
accepted: 06 12 2019
entrez: 25 12 2019
pubmed: 25 12 2019
medline: 25 12 2019
Statut: epublish

Résumé

We aimed to compare different methods for semi-quantitative analysis of cardiac retention of bone tracers in patients with cardiac transthyretin amyloidosis (ATTR). Data from 67 patients with ATTR who underwent both conventional whole-body scan and a CZT myocardial SPECT (DSPECT, Spectrum Dynamics) 3 h after injection of H:Bs obtained from planar and reprojected data were not statistically different (wb-H:B, 2.05 ± 0.64, ant-H:B, 1.97 ± 0.61, LAO-H:B, 2.06 ± 0.64, all p = ns). However, 3D-H:B was increased compared to planar H:Bs (3D-H:B, 4.06 ± 1.77, all p < 0.0001 vs. wb-H:B, ant-H:B, and LAO-H:B). Bland-Altman plots demonstrated that the difference between 3D and planar H:Bs increased with the mean value of myocardial uptake. 3D-H:B was best correlated to septal thickness (r = 0.45, p < 0.001). Finally, abnormal right ventricular uptake was associated with higher values of cardiac retention. 3D semi-quantitative analysis of CZT SPECT optimized the assessment of

Identifiants

pubmed: 31873816
doi: 10.1186/s13550-019-0584-8
pii: 10.1186/s13550-019-0584-8
pmc: PMC6928186
doi:

Types de publication

Journal Article

Langues

eng

Pagination

117

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Auteurs

Alain Manrique (A)

Department of Nuclear Medicine, Normandie Univ, UNICAEN, EA4650 SEILIRM, CHU de Caen, 14000, Caen, France. manrique@cyceron.fr.
GIP Cyceron, Campus Jules Horowitz, Boulevard Henri Becquerel, BP 5229, 14074, Caen, France. manrique@cyceron.fr.

David Dudoignon (D)

Department of Nuclear Medicine, Normandie Univ, UNICAEN, EA4650 SEILIRM, CHU de Caen, 14000, Caen, France.

Stéphanie Brun (S)

Department of Nuclear Medicine, Toulouse University Hospital, Toulouse, France.
Medical School, Toulouse III Paul Sabatier University, Toulouse, France.

Catherine N'Ganoa (C)

Department of Nuclear Medicine, Normandie Univ, UNICAEN, EA4650 SEILIRM, CHU de Caen, 14000, Caen, France.

Emmanuelle Cassol (E)

Department of Nuclear Medicine, Toulouse University Hospital, Toulouse, France.
Medical School, Toulouse III Paul Sabatier University, Toulouse, France.

Damien Legallois (D)

Department of Cardiology, Normandie Univ, UNICAEN, EA4650 SEILIRM, CHU de Caen, 14000, Caen, France.

Yoan Lavie-Badie (Y)

Department of Cardiology, Rangueil University Hospital, Toulouse, France.

Denis Agostini (D)

Department of Nuclear Medicine, Normandie Univ, UNICAEN, EA4650 SEILIRM, CHU de Caen, 14000, Caen, France.

Olivier Lairez (O)

Department of Nuclear Medicine, Toulouse University Hospital, Toulouse, France.
Medical School, Toulouse III Paul Sabatier University, Toulouse, France.

Classifications MeSH