Automated Quantification of Macular Ellipsoid Zone Intensity in Glaucoma Patients: the Method and its Comparison with Manual Quantification.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 12 2019
24 12 2019
Historique:
received:
06
08
2019
accepted:
05
12
2019
entrez:
26
12
2019
pubmed:
26
12
2019
medline:
6
11
2020
Statut:
epublish
Résumé
The macular ellipsoid zone intensity (mEZi) is a known marker of disease severity in a number of diverse ocular diseases. The purpose of this study was to establish an automated method (AM) for mEZi quantification and to compare the method's performance with that of a manual method (MM) for glaucoma patients and healthy controls. Seventy-one (71) mild-to-moderate glaucoma patients, 71 severe-glaucoma patients, and 51 controls were enrolled. Both calibration (n = 160) and validation (n = 33) image sets were compiled. The correlation of AM to MM quantification was assessed by Deming regression for the calibration set, and a compensation formula was generated. Then, for each image in the validation set, the compensated AM quantification was compared with the mean of five repetitive MM quantifications. The AM quantification of the calibration set was found to be linearly correlated with MM in the normal-to-severe-stage glaucoma patients (R
Identifiants
pubmed: 31875050
doi: 10.1038/s41598-019-56337-7
pii: 10.1038/s41598-019-56337-7
pmc: PMC6930206
doi:
Types de publication
Clinical Trial
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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