Secondary Pulmonary Alveolar Proteinosis Following Treatment with Azacitidine for Myelodysplastic Syndrome.
azacitidine
myelodysplastic syndromes
secondary pulmonary alveolar proteinosis
umbilical cord blood transplantation
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
15 Apr 2020
15 Apr 2020
Historique:
pubmed:
26
12
2019
medline:
2
10
2020
entrez:
26
12
2019
Statut:
ppublish
Résumé
Secondary pulmonary alveolar proteinosis (sPAP) is a complication of myelodysplastic syndrome (MDS). A 60-year-old woman was diagnosed with MDS with excess blasts-1. Fifty-four months after the initial diagnosis, treatment with azacitidine was initiated. Seventy-three months after the diagnosis, a bone marrow examination revealed increased myeloblasts, at which time computed tomography showed diffuse ground-glass opacities and interlobular septal thickening in the bilateral lower lung fields. A lung biopsy revealed the presence of PAP; therefore, the clinical diagnosis of MDS/sPAP was confirmed. Careful attention should be paid to the development of sPAP in MDS patients with pulmonary lesions during azacitidine treatment.
Identifiants
pubmed: 31875636
doi: 10.2169/internalmedicine.3770-19
pmc: PMC7205539
doi:
Substances chimiques
Azacitidine
M801H13NRU
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1081-1086Commentaires et corrections
Type : CommentIn
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