Lesional and non-lesional epilepsies: A blurring genetic boundary.
Epileptogenic structural abnormalities
Genetic epilepsies
Neurodevelopmental disorders with epilepsy
Phenotypic and genetic heterogeneity
Journal
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
ISSN: 1532-2130
Titre abrégé: Eur J Paediatr Neurol
Pays: England
ID NLM: 9715169
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
22
08
2019
revised:
05
12
2019
accepted:
06
12
2019
pubmed:
27
12
2019
medline:
28
7
2020
entrez:
27
12
2019
Statut:
ppublish
Résumé
There has been a traditional conceptual partition between the so-called non-lesional genetic epilepsies and the genetically determined interposed epileptogenic structural abnormalities. In this review, we summarise how growing evidence acquired through neuroimaging and neurobiology modelling is demonstrating that a distinction between lesional and functional (or non-lesional) epileptogenesis is less obvious than previously thought, particularly for epileptogenic neurodevelopmental disorders, but also for most genetically determined epilepsies.
Identifiants
pubmed: 31875834
pii: S1090-3798(19)30433-7
doi: 10.1016/j.ejpn.2019.12.013
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
24-29Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare to have no conflict of interest related to the contents of this article.