Trajectories of kidney function and associated factors among community-dwelling older Japanese: a 16-year longitudinal study.
Chronic kidney disease (CKD)
Community dwelling
Older adults
Trajectories
eGFR
Journal
Clinical and experimental nephrology
ISSN: 1437-7799
Titre abrégé: Clin Exp Nephrol
Pays: Japan
ID NLM: 9709923
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
30
04
2019
accepted:
13
12
2019
pubmed:
27
12
2019
medline:
14
1
2021
entrez:
27
12
2019
Statut:
ppublish
Résumé
No study has reported trajectories of kidney function in later life. This long-term prospective study attempted to classify trajectories of estimated glomerular filtration rate (eGFR) and identify factors associated with these trajectories. We collected data from annual geriatric health checkups conducted during 2002-2017 in Kusatsu Town, Gunma Prefecture, Japan. The participants were 1990 adults aged 65-90 years (mean [SD] age, 71.0 [5.7] years; 57.0% women), and the total number of observations was 9291. Data were analyzed with a group-based semiparametric mixture model and age-adjusted univariable cumulative logit models. Trajectory of kidney function, as determined by eGFR, was classified as low, middle, and high (4.8%, 38.9%, and 56.3% of men, respectively, and 5.2%, 31.5%, and 63.3% of women). Among men and women in the low trajectory group, chronic kidney disease (CKD) stage worsened from stage G3a (51.8 ml/min/1.73 m About 5% of community-dwelling older adults had an eGFR < 30 later in life. Our findings suggest that those with stage G3a CKD at age 65 years should be managed intensively, to control risk factors for CKD progression.
Sections du résumé
BACKGROUND
BACKGROUND
No study has reported trajectories of kidney function in later life. This long-term prospective study attempted to classify trajectories of estimated glomerular filtration rate (eGFR) and identify factors associated with these trajectories.
METHODS
METHODS
We collected data from annual geriatric health checkups conducted during 2002-2017 in Kusatsu Town, Gunma Prefecture, Japan. The participants were 1990 adults aged 65-90 years (mean [SD] age, 71.0 [5.7] years; 57.0% women), and the total number of observations was 9291. Data were analyzed with a group-based semiparametric mixture model and age-adjusted univariable cumulative logit models.
RESULTS
RESULTS
Trajectory of kidney function, as determined by eGFR, was classified as low, middle, and high (4.8%, 38.9%, and 56.3% of men, respectively, and 5.2%, 31.5%, and 63.3% of women). Among men and women in the low trajectory group, chronic kidney disease (CKD) stage worsened from stage G3a (51.8 ml/min/1.73 m
CONCLUSIONS
CONCLUSIONS
About 5% of community-dwelling older adults had an eGFR < 30 later in life. Our findings suggest that those with stage G3a CKD at age 65 years should be managed intensively, to control risk factors for CKD progression.
Identifiants
pubmed: 31875938
doi: 10.1007/s10157-019-01837-z
pii: 10.1007/s10157-019-01837-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
330-338Références
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
J Am Med Dir Assoc. 2017 Feb 1;18(2):192.e13-192.e20
pubmed: 28049615
Fam Pract. 1994 Sep;11(3):260-6
pubmed: 7843514
Arch Intern Med. 2002 Jun 24;162(12):1401-8
pubmed: 12076240
Am J Kidney Dis. 2012 Apr;59(4):513-22
pubmed: 22305760
J Gerontol A Biol Sci Med Sci. 2019 Jan 16;74(2):211-218
pubmed: 29596617
J Gerontol A Biol Sci Med Sci. 2014 Oct;69(10):1276-83
pubmed: 24488214
Circulation. 2013 Sep 10;128(11):1198-205
pubmed: 23902756
Arch Gerontol Geriatr. 1991 Sep-Oct;13(2):103-16
pubmed: 15374421
J Am Coll Cardiol. 2008 Jul 1;52(1):71-9
pubmed: 18582638
J Gerontol A Biol Sci Med Sci. 2016 Nov;71(11):1492-1499
pubmed: 26933162
Kidney Int Suppl. 1999 Jul;71:S47-50
pubmed: 10412736
Am J Kidney Dis. 2009 Jun;53(6):982-92
pubmed: 19339088
Kidney Int. 2000 Jul;58(1):293-301
pubmed: 10886574
Nihon Koshu Eisei Zasshi. 2003 Dec;50(12):1117-24
pubmed: 14750363
Kidney Int. 2007 Jan;71(2):159-66
pubmed: 17136030
Kidney Int. 2017 Jan;91(1):227-234
pubmed: 27884399
Clin J Am Soc Nephrol. 2011 Nov;6(11):2605-11
pubmed: 21921154
Clin Exp Nephrol. 2013 Apr;17(2):225-31
pubmed: 22911116
PLoS One. 2014 Jun 12;9(6):e99487
pubmed: 24923425
J Am Soc Nephrol. 2012 Oct;23(10):1631-4
pubmed: 22935483
Arch Intern Med. 2006 Jul 10;166(13):1380-8
pubmed: 16832003
Am J Kidney Dis. 2018 Jan;71(1):91-101
pubmed: 29153995
Semin Dial. 2004 Nov-Dec;17(6):432-7
pubmed: 15660573
Lancet. 2017 Mar 25;389(10075):1238-1252
pubmed: 27887750
Clin Exp Nephrol. 2009 Dec;13(6):621-30
pubmed: 19513802
Br J Clin Pharmacol. 1982 Jan;13(1):107-15
pubmed: 7066149
J Am Med Dir Assoc. 2015 Apr;16(4):349.e1-5
pubmed: 25669668