Hippocampal long-term synaptic depression and memory deficits induced in early amyloidopathy are prevented by enhancing G-protein-gated inwardly rectifying potassium channel activity.
Amyloid beta-Peptides
/ toxicity
Amyloidosis
/ chemically induced
Animals
Excitatory Postsynaptic Potentials
/ drug effects
G Protein-Coupled Inwardly-Rectifying Potassium Channels
/ metabolism
Hippocampus
/ drug effects
Long-Term Synaptic Depression
/ drug effects
Male
Memory Disorders
/ chemically induced
Mice
Mice, Inbred C57BL
Organ Culture Techniques
Peptide Fragments
/ toxicity
Potassium Channels, Inwardly Rectifying
/ metabolism
Receptors, G-Protein-Coupled
/ metabolism
GirK channels
LABORAS
amyloid-β1-42 peptide
brain slices
habituation
hippocampus
synaptic plasticity
Journal
Journal of neurochemistry
ISSN: 1471-4159
Titre abrégé: J Neurochem
Pays: England
ID NLM: 2985190R
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
26
05
2019
revised:
06
12
2019
accepted:
20
12
2019
pubmed:
27
12
2019
medline:
5
11
2020
entrez:
27
12
2019
Statut:
ppublish
Résumé
Hippocampal synaptic plasticity disruption by amyloid-β (Aβ) peptides + thought to be responsible for learning and memory impairments in Alzheimer's disease (AD) early stage. Failures in neuronal excitability maintenance seems to be an underlying mechanism. G-protein-gated inwardly rectifying potassium (GirK) channels control neural excitability by hyperpolarization in response to many G-protein-coupled receptors activation. Here, in early in vitro and in vivo amyloidosis mouse models, we study whether GirK channels take part of the hippocampal synaptic plasticity impairments generated by Aβ
Identifiants
pubmed: 31875959
doi: 10.1111/jnc.14946
pmc: PMC7217154
doi:
Substances chimiques
Amyloid beta-Peptides
0
G Protein-Coupled Inwardly-Rectifying Potassium Channels
0
Peptide Fragments
0
Potassium Channels, Inwardly Rectifying
0
Receptors, G-Protein-Coupled
0
amyloid beta-protein (1-42)
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
362-376Informations de copyright
© 2019 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry.
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