Recovery cycles of posterior root-muscle reflexes evoked by transcutaneous spinal cord stimulation and of the H reflex in individuals with intact and injured spinal cord.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
12
07
2019
accepted:
10
12
2019
entrez:
27
12
2019
pubmed:
27
12
2019
medline:
3
4
2020
Statut:
epublish
Résumé
Posterior root-muscle (PRM) reflexes are short-latency spinal reflexes evoked by epidural or transcutaneous spinal cord stimulation (SCS) in clinical and physiological studies. PRM reflexes share key physiological characteristics with the H reflex elicited by electrical stimulation of large-diameter muscle spindle afferents in the tibial nerve. Here, we compared the H reflex and the PRM reflex of soleus in response to transcutaneous stimulation by studying their recovery cycles in ten neurologically intact volunteers and ten individuals with traumatic, chronic spinal cord injury (SCI). The recovery cycles of the reflexes, i.e., the time course of their excitability changes, were assessed by paired pulses with conditioning-test intervals of 20-5000 ms. Between the subject groups, no statistical difference was found for the recovery cycles of the H reflexes, yet those of the PRM reflexes differed significantly, with a striking suppression in the intact group. When comparing the reflex types, they did not differ in the SCI group, while the PRM reflexes were more strongly depressed in the intact group for durations characteristic for presynaptic inhibition. These differences may arise from the concomitant stimulation of several posterior roots containing afferent fibers of various lower extremity nerves by transcutaneous SCS, producing multi-source heteronymous presynaptic inhibition, and the collective dysfunction of inhibitory mechanisms after SCI contributing to spasticity. PRM-reflex recovery cycles additionally obtained for bilateral rectus femoris, biceps femoris, tibialis anterior, and soleus all demonstrated a stronger suppression in the intact group. Within both subject groups, the thigh muscles showed a stronger recovery than the lower leg muscles, which may reflect a characteristic difference in motor control of diverse muscles. Based on the substantial difference between intact and SCI individuals, PRM-reflex depression tested with paired pulses could become a sensitive measure for spasticity and motor recovery.
Identifiants
pubmed: 31877192
doi: 10.1371/journal.pone.0227057
pii: PONE-D-19-19666
pmc: PMC6932776
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0227057Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Spinal Cord. 2000 Aug;38(8):473-89
pubmed: 10962608
Brain Res. 1966 Aug;2(2):192-4
pubmed: 5968923
J Neurophysiol. 2010 May;103(5):2808-20
pubmed: 20357075
Exp Brain Res. 2019 Feb;237(2):467-476
pubmed: 30460394
Brain. 1969 Mar;92(1):203-12
pubmed: 5774028
Muscle Nerve. 1993 Jun;16(6):648-54
pubmed: 8389002
Neurorehabil Neural Repair. 2010 Jan;24(1):23-33
pubmed: 19723923
Bull Johns Hopkins Hosp. 1950 May;86(5):265-90
pubmed: 15414383
Conf Proc IEEE Eng Med Biol Soc. 2007;2007:2713-6
pubmed: 18002555
Artif Organs. 2015 Oct;39(10):E176-86
pubmed: 26450344
Exp Brain Res. 1989;78(1):28-32
pubmed: 2591515
J Neurophysiol. 1971 Nov;34(6):1010-7
pubmed: 4329961
Brain. 1995 Aug;118 ( Pt 4):995-1004
pubmed: 7655894
PLoS One. 2019 Apr 4;14(4):e0214818
pubmed: 30947310
Phys Med Rehabil Clin N Am. 2014 Aug;25(3):505-17, vii
pubmed: 25064785
J Physiol. 1957 Feb 15;135(2):400-11
pubmed: 13406749
J Physiol. 1987 Apr;385:69-87
pubmed: 2958622
Exp Brain Res. 2005 Oct;166(2):248-62
pubmed: 16078020
Drug Metab Dispos. 1999 Feb;27(2):201-4
pubmed: 9929503
J Neurol Neurosurg Psychiatry. 1976 Jun;39(6):545-54
pubmed: 950566
J Rehabil Res Dev. 1989 Fall;26(4):9-16
pubmed: 2600869
J Neurol Neurosurg Psychiatry. 1967 Oct;30(5):427-31
pubmed: 6062993
Front Neurol. 2017 Feb 03;8:17
pubmed: 28217104
Phys Ther. 1987 Feb;67(2):206-7
pubmed: 3809245
Eur J Clin Pharmacol. 1985;29(4):467-9
pubmed: 3912190
Exp Brain Res. 1997 Sep;116(2):375-80
pubmed: 9348136
J Physiol. 1962 May;161:282-97
pubmed: 13889059
J Neurosci Methods. 2008 Jun 15;171(1):1-12
pubmed: 18394711
J Neurotrauma. 2019 Aug 9;:null
pubmed: 31333064
Fundam Clin Pharmacol. 1987;1(6):479-88
pubmed: 3447935
Nature. 2018 Nov;563(7729):65-71
pubmed: 30382197
Electroencephalogr Clin Neurophysiol. 1993 Jun;89(3):177-86
pubmed: 7686850
J Physiol. 1987 Aug;389:729-56
pubmed: 3681741
Hum Mov Sci. 2007 Apr;26(2):275-95
pubmed: 17343947
Exp Neurol. 1966 May;15(1):140-56
pubmed: 5934660
Brain. 2001 Apr;124(Pt 4):826-37
pubmed: 11287381
J Neurophysiol. 1984 Sep;52(3):435-48
pubmed: 6090608
Arzneimittelforschung. 1987 Feb;37(2):199-202
pubmed: 2883980
Brain. 1996 Aug;119 ( Pt 4):1099-105
pubmed: 8813274
Expert Opin Pharmacother. 2008 Aug;9(12):2209-15
pubmed: 18671474
Neurophysiol Clin. 2000 Apr;30(2):67-80
pubmed: 10812576
Exp Brain Res. 1996 Mar;108(3):450-62
pubmed: 8801125
Bull Johns Hopkins Hosp. 1951 Jun;88(6):499-519
pubmed: 14839348
Front Neurosci. 2017 Jun 08;11:333
pubmed: 28642680
Exp Brain Res. 2000 Jul;133(2):233-41
pubmed: 10968224
Bull Johns Hopkins Hosp. 1951 Jun;88(6):520-37
pubmed: 14839349
J Physiol. 1983 Jun;339:535-52
pubmed: 6887033
Artif Organs. 2008 Aug;32(8):644-8
pubmed: 18782137
J Physiol Paris. 1999 Sep-Oct;93(4):379-85
pubmed: 10574126
Exp Brain Res. 1984;56(2):341-50
pubmed: 6090196
J Neurosci. 2013 Dec 4;33(49):19326-40
pubmed: 24305828
Electroencephalogr Clin Neurophysiol. 1998 Feb;109(1):10-4
pubmed: 11003059
Exp Brain Res. 1993;97(1):173-6
pubmed: 8131827
J Physiol. 1990 Apr;423:661-75
pubmed: 2388162
Arch Phys Med Rehabil. 2006 Jan;87(1):71-5
pubmed: 16401441
Neurosci Lett. 2015 Mar 4;589:144-9
pubmed: 25600855
Acta Physiol Scand. 1964 Aug;61:331-47
pubmed: 14209252
J Physiol. 1954 Dec 10;126(3):524-62
pubmed: 13222354
Exp Brain Res. 1993;96(3):534-44
pubmed: 8299754
J Neurotrauma. 2019 May 1;36(9):1451-1460
pubmed: 30430902
Muscle Nerve. 2007 Mar;35(3):327-36
pubmed: 17117411
J Neurol Neurosurg Psychiatry. 1967 Aug;30(4):325-31
pubmed: 6055341
Arzneimittelforschung. 1984;34(6):724-9
pubmed: 6148954
Neurosci Lett. 1984 Feb 10;44(2):137-42
pubmed: 6231494
Neuroscientist. 2017 Dec;23(6):649-663
pubmed: 28351197
J Physiol. 1964 Dec;175:100-12
pubmed: 14241151
Spinal Cord. 2000 Jul;38(7):394-402
pubmed: 10962598
J Physiol. 2007 Aug 1;582(Pt 3):1125-39
pubmed: 17446226
Prog Neurobiol. 1987;28(4):345-76
pubmed: 3588965
Artif Organs. 2011 Mar;35(3):257-62
pubmed: 21401670
Pflugers Arch Gesamte Physiol Menschen Tiere. 1951;253(3):286-300
pubmed: 14833863
Neurorehabil Neural Repair. 2016 Mar;30(3):233-43
pubmed: 26089308
J Neurotrauma. 2019 May 1;36(9):1435-1450
pubmed: 30362876
Nat Med. 2018 Nov;24(11):1677-1682
pubmed: 30250140
N Engl J Med. 2018 Sep 27;379(13):1244-1250
pubmed: 30247091
Morphol Med. 1983 May;3(1):27-46
pubmed: 6877253
Exp Brain Res. 2008 Feb;185(2):189-97
pubmed: 17932663
Nat Neurosci. 2018 Dec;21(12):1728-1741
pubmed: 30382196
J Physiol. 1994 May 15;477(Pt 1):47-58
pubmed: 8071888
J Neurophysiol. 2014 Mar;111(5):1088-99
pubmed: 24335213
Brain. 1994 Dec;117 ( Pt 6):1449-55
pubmed: 7820579
J Neurophysiol. 2015 Jul;114(1):485-92
pubmed: 25995355
Exp Neurol. 1978 Jun;60(2):380-5
pubmed: 658210
Muscle Nerve. 1998 Mar;21(3):352-60
pubmed: 9486864
J Neurosci Methods. 2009 May 30;180(1):111-5
pubmed: 19427537
IEEE Trans Neural Syst Rehabil Eng. 2010 Dec;18(6):637-45
pubmed: 21138794
PLoS One. 2018 Jan 30;13(1):e0192013
pubmed: 29381748
Spinal Cord. 2004 Jul;42(7):401-16
pubmed: 15124000
Jpn J Physiol. 1964 Aug 15;14:411-21
pubmed: 14200821
J Spinal Cord Med. 2014 Mar;37(2):202-11
pubmed: 24090290
Neurology. 1994 Nov;44(11 Suppl 9):S21-7; discussion S27-8
pubmed: 7970007