Reduced pancreatic polypeptide response is associated with early alteration of glycemic control in chronic pancreatitis.
C-peptide response
Chronic pancreatitis
Glucose intolerance
Oral glucose tolerance test
Pancreatic polypeptide response
Pancreatogenic diabetes
Journal
Diabetes research and clinical practice
ISSN: 1872-8227
Titre abrégé: Diabetes Res Clin Pract
Pays: Ireland
ID NLM: 8508335
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
21
10
2019
revised:
25
11
2019
accepted:
20
12
2019
pubmed:
27
12
2019
medline:
4
6
2020
entrez:
27
12
2019
Statut:
ppublish
Résumé
To study the incidence of glucose intolerance in CP patients without diabetes by performing oral glucose tolerance test (OGTT). We screened consecutive Indian CP patients without diabetes over 6 months by performing OGTT and correlated with physical characteristics and glycated hemoglobin (HbA1c). We also compared c-peptide and pancreatic polypeptide response in different groups based on OGTT. Relevant statistical tests were performed. P < 0.05 was considered significant. Total of 171 patients were screened. Mean duration of CP was 5.03 ± 4.32 years. 55 were detected to have prediabetes and 40 DM on OGTT. CP patients with diabetes and prediabetes had significantly dilated pancreatic duct compared to non-diabetic CP (4.2 ± 2.7 mm, 3.6 ± 2.7 mm, 2.84 ± 2.25 mm; p = 0.018). Fasting blood glucose (FBS) and 2-hour OGTT were 109.35 ± 19.06, 97.47 ± 11.94, 85.24 ± 9.95 and 236.13 ± 31.42, 154.65 ± 19.53, 112.89 ± 16.32 in patients with DM, prediabetes and CP patients without diabetes (p < 0.0001). There was a good c-peptide response (p = 0.001) and reduced pancreatic polypeptide response (p = 0.003) in CP patients compared to controls. Early in the course of disease reduced pancreatic polypeptide response in the presence of good c-peptide response may result in development of DM.
Identifiants
pubmed: 31877344
pii: S0168-8227(19)31524-4
doi: 10.1016/j.diabres.2019.107993
pii:
doi:
Substances chimiques
Blood Glucose
0
C-Peptide
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
107993Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors whose names are listed immediately above certify that they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.