Recent developments of chalcones as potential antibacterial agents in medicinal chemistry.
Antibacterial
Chalcone
Mechanism
Structure−activity relationships
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
01 Feb 2020
01 Feb 2020
Historique:
received:
30
07
2019
revised:
13
12
2019
accepted:
16
12
2019
pubmed:
27
12
2019
medline:
11
3
2020
entrez:
27
12
2019
Statut:
ppublish
Résumé
Chalcones, containing an α,β-unsaturated ketone fragment, are an important pharmacologically active agents because of their diverse mechanisms. This review provides an update on the recent developments (2009-2019.3) in the antibacterial activity of natural and synthetic chalcones. Moreover, the structure-activity relationships and mechanisms are also carefully summarized which will provide some important guidance for design and synthesis in future. This comprehensive and critical review will be helpful for medicinal chemists to develop more candidate antibacterial agents.
Identifiants
pubmed: 31877539
pii: S0223-5234(19)31132-8
doi: 10.1016/j.ejmech.2019.111980
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Chalcones
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111980Informations de copyright
Copyright © 2019 Elsevier Masson SAS. All rights reserved.