Interplay of an Obesity-Based Genetic Risk Score with Dietary and Endocrine Factors on Insulin Resistance.
diet
genetic risk score
insulin resistance
metabolic factors
obesity
personalized nutrition
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
21 Dec 2019
21 Dec 2019
Historique:
received:
28
11
2019
revised:
13
12
2019
accepted:
18
12
2019
entrez:
28
12
2019
pubmed:
28
12
2019
medline:
28
8
2020
Statut:
epublish
Résumé
This study aimed to nutrigenetically screen gene-diet and gene-metabolic interactions influencing insulin resistance (IR) phenotypes. A total of 232 obese or overweight adults were categorized by IR status: non-IR (HOMA-IR (homeostatic model assessment - insulin resistance) index ≤ 2.5) and IR (HOMA-IR index > 2.5). A weighted genetic risk score (wGRS) was constructed using 95 single nucleotide polymorphisms related to energy homeostasis, which were genotyped by a next generation sequencing system. Body composition, the metabolic profile and lifestyle variables were evaluated, where individuals with IR showed worse metabolic outcomes. Overall, 16 obesity-predisposing genetic variants were associated with IR (
Identifiants
pubmed: 31877696
pii: nu12010033
doi: 10.3390/nu12010033
pmc: PMC7019905
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Gobierno de Navarra
ID : PT024
Organisme : Centro de Investigación Biomédica en Red: Fisiopatología de la Obesidad y Nutrición
ID : CB12/03/30002
Organisme : Nutrición personalizada y biomarcadores nutrigenómicos de la inflamación asociada a la dieta y la obesidad
ID : AGL2013-45554-R
Organisme : MINECO
ID : AGL2013-45554-R
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