ABC Transporters at the Blood-Brain Interfaces, Their Study Models, and Drug Delivery Implications in Gliomas.
ABC transporters
arachnoid barrier (BAB)
blood–brain barrier (BBB)
blood–brain tumor barrier (BBTB)
blood–cerebrospinal fluid barrier (BCSFB)
drug delivery
glioma
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
23 Dec 2019
23 Dec 2019
Historique:
received:
14
11
2019
revised:
13
12
2019
accepted:
20
12
2019
entrez:
28
12
2019
pubmed:
28
12
2019
medline:
28
12
2019
Statut:
epublish
Résumé
Drug delivery into the brain is regulated by the blood-brain interfaces. The blood-brain barrier (BBB), the blood-cerebrospinal fluid barrier (BCSFB), and the blood-arachnoid barrier (BAB) regulate the exchange of substances between the blood and brain parenchyma. These selective barriers present a high impermeability to most substances, with the selective transport of nutrients and transporters preventing the entry and accumulation of possibly toxic molecules, comprising many therapeutic drugs. Transporters of the ATP-binding cassette (ABC) superfamily have an important role in drug delivery, because they extrude a broad molecular diversity of xenobiotics, including several anticancer drugs, preventing their entry into the brain. Gliomas are the most common primary tumors diagnosed in adults, which are often characterized by a poor prognosis, notably in the case of high-grade gliomas. Therapeutic treatments frequently fail due to the difficulty of delivering drugs through the brain barriers, adding to diverse mechanisms developed by the cancer, including the overexpression or expression de novo of ABC transporters in tumoral cells and/or in the endothelial cells forming the blood-brain tumor barrier (BBTB). Many models have been developed to study the phenotype, molecular characteristics, and function of the blood-brain interfaces as well as to evaluate drug permeability into the brain. These include in vitro, in vivo, and in silico models, which together can help us to better understand their implication in drug resistance and to develop new therapeutics or delivery strategies to improve the treatment of pathologies of the central nervous system (CNS). In this review, we present the principal characteristics of the blood-brain interfaces; then, we focus on the ABC transporters present on them and their implication in drug delivery; next, we present some of the most important models used for the study of drug transport; finally, we summarize the implication of ABC transporters in glioma and the BBTB in drug resistance and the strategies to improve the delivery of CNS anticancer drugs.
Identifiants
pubmed: 31878061
pii: pharmaceutics12010020
doi: 10.3390/pharmaceutics12010020
pmc: PMC7022905
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
J Neurochem. 2018 Sep;146(6):670-685
pubmed: 29675872
J Pharmacol Exp Ther. 2004 Jun;309(3):1221-9
pubmed: 14762102
J Pharm Sci. 2016 Jan;105(1):350-8
pubmed: 26554626
J Neurochem. 2003 Nov;87(4):820-30
pubmed: 14622113
AAPS J. 2017 Sep;19(5):1317-1331
pubmed: 28664465
Fluids Barriers CNS. 2014 Nov 14;11(1):25
pubmed: 25414790
J Neurochem. 2004 May;89(3):788-800
pubmed: 15086534
Int J Nanomedicine. 2012;7:2473-81
pubmed: 22701315
Expert Opin Drug Deliv. 2011 Mar;8(3):389-401
pubmed: 21314230
Proc Natl Acad Sci U S A. 1989 Jan;86(2):695-8
pubmed: 2563168
Annu Rev Pharmacol Toxicol. 2012;52:249-73
pubmed: 21942630
Neurosurgery. 1997 Jul;41(1):44-8; discussion 48-9
pubmed: 9218294
J Pharmacol Exp Ther. 2013 Dec;347(3):755-64
pubmed: 24113148
J Med Invest. 2005 Feb;52(1-2):41-8
pubmed: 15751272
Kidney Int Suppl. 1998 Sep;67:S100-8
pubmed: 9736263
J Pharmacol Exp Ther. 2006 Jun;317(3):1012-8
pubmed: 16537797
J Neurooncol. 2004 Jan;66(1-2):65-70
pubmed: 15015771
Neuroimage. 2003 Nov;20(3):1775-82
pubmed: 14642487
F1000Res. 2016 Mar 10;5:
pubmed: 26998242
Acta Neuropathol. 2012 Dec;124(6):763-75
pubmed: 23143192
Cancer Res. 2003 Apr 1;63(7):1515-9
pubmed: 12670898
J Cell Sci. 1993 Mar;104 ( Pt 3):773-82
pubmed: 8314872
Am J Physiol. 1994 Jan;266(1 Pt 2):R292-305
pubmed: 8304553
Neurobiol Dis. 2010 Jan;37(1):13-25
pubmed: 19664713
J Pharmacol Exp Ther. 2011 Dec;339(3):935-44
pubmed: 21934030
Sci Rep. 2014 Feb 24;4:4160
pubmed: 24561821
J Bioenerg Biomembr. 2001 Dec;33(6):453-8
pubmed: 11804186
J Neurochem. 2005 Oct;95(1):294-304
pubmed: 16181433
J Pharmacol Exp Ther. 2015 Nov;355(2):264-71
pubmed: 26354993
Sci Rep. 2017 Apr 4;7(1):603
pubmed: 28377615
J Neurosurg. 2019 Aug 2;:1-10
pubmed: 31374547
Science. 2015 Jan 23;347(6220):1260419
pubmed: 25613900
Genome Res. 2000 Sep;10(9):1393-402
pubmed: 10984457
Mol Pharmacol. 2019 Aug;96(2):138-147
pubmed: 31189668
Cell Mol Neurobiol. 2005 Feb;25(1):41-58
pubmed: 15962508
Mol Pharmacol. 2000 Dec;58(6):1357-67
pubmed: 11093774
Front Cell Neurosci. 2019 Jun 06;13:230
pubmed: 31244605
Int J Biochem Mol Biol. 2012;3(1):1-27
pubmed: 22509477
Clin Pharmacol Ther. 2019 Sep;106(3):525-543
pubmed: 31175671
Oncotarget. 2012 Jun;3(6):640-50
pubmed: 22791660
Mol Cancer Ther. 2015 Dec;14(12):2735-43
pubmed: 26438157
Pharmacol Rev. 2006 Jun;58(2):140-61
pubmed: 16714484
Blood Purif. 1995;13(3-4):112-24
pubmed: 7619383
J Med Chem. 2009 Oct 8;52(19):6073-82
pubmed: 19711894
Curr Pharm Biotechnol. 2011 Apr;12(4):595-608
pubmed: 21118093
Neuro Oncol. 2013 Feb;15(2):189-97
pubmed: 23262509
Biomaterials. 2012 Jan;33(2):704-12
pubmed: 22019122
J Neurosci. 2014 Sep 3;34(36):11929-47
pubmed: 25186741
J Vis Exp. 2015 Nov 10;(105):e53208
pubmed: 26574794
Brain Res. 2004 Sep 17;1021(1):32-40
pubmed: 15328029
J Clin Pharmacol. 2016 Jul;56 Suppl 7:S143-56
pubmed: 27385172
Nat Rev Clin Oncol. 2017 Jul;14(7):434-452
pubmed: 28031556
Cell Death Dis. 2018 Feb 7;9(2):190
pubmed: 29416017
Nucl Med Biol. 2010 Jul;37(5):637-44
pubmed: 20610168
Colloids Surf B Biointerfaces. 2016 Nov 1;147:242-249
pubmed: 27518456
Mol Pharm. 2014 Jul 7;11(7):1949-63
pubmed: 24641309
J Neurooncol. 2005 Sep;74(2):113-21
pubmed: 16193381
Drug Metab Dispos. 2009 Mar;37(3):635-43
pubmed: 19047468
Pharmacogenomics. 2010 Oct;11(10):1427-38
pubmed: 21047204
Acta Neuropathol. 2018 Mar;135(3):363-385
pubmed: 29368214
Adv Drug Deliv Rev. 1999 Apr 5;36(2-3):179-194
pubmed: 10837715
J Cell Physiol. 2011 Jan;226(1):255-66
pubmed: 20665675
J Neurosurg. 2010 Aug;113(2):301-9
pubmed: 20020841
Clin Cancer Res. 2012 Nov 15;18(22):6239-48
pubmed: 22992516
Pharm Res. 2003 Jun;20(6):904-9
pubmed: 12817896
Mol Pharm. 2019 May 6;16(5):2021-2027
pubmed: 30977661
Cancer Res. 2004 Oct 1;64(19):6892-9
pubmed: 15466178
Cancer Invest. 2006 Aug-Sep;24(5):528-34
pubmed: 16939963
Cancer Cell. 2002 Mar;1(2):157-68
pubmed: 12086874
Neurosurg Focus. 2012 Jan;32(1):E3
pubmed: 22208896
Br J Cancer. 1997;76(4):445-50
pubmed: 9275020
Nat Rev Dis Primers. 2015 Jul 16;1:15017
pubmed: 27188790
Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4721-8
pubmed: 18614809
Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1611-6
pubmed: 23300285
FASEB J. 2005 Nov;19(13):1872-4
pubmed: 16141364
Epilepsia. 2007 Mar;48(3):505-16
pubmed: 17326793
Int J Pharm. 2011 Feb 14;404(1-2):36-41
pubmed: 21056096
Brain Res Brain Res Rev. 2005 Dec 15;50(2):258-65
pubmed: 16199092
J Pharm Sci. 2015 Sep;104(9):2727-46
pubmed: 25630899
Nat Rev Drug Discov. 2010 Mar;9(3):215-36
pubmed: 20190787
Nature. 2018 May;557(7707):S55-S57
pubmed: 29849160
J Cereb Blood Flow Metab. 2009 Mar;29(3):504-11
pubmed: 18985052
Expert Opin Drug Discov. 2017 Jan;12(1):89-103
pubmed: 27782770
Methods Mol Biol. 2018;1727:315-331
pubmed: 29222791
Bioorg Med Chem. 2017 Aug 1;25(15):4194-4202
pubmed: 28645831
Mol Cell Biol. 2004 Sep;24(17):7612-21
pubmed: 15314169
PLoS One. 2014 Jan 02;9(1):e84179
pubmed: 24392113
Curr Med Chem. 2008;15(20):1981-2039
pubmed: 18691054
Mol Cancer Ther. 2002 Apr;1(6):417-25
pubmed: 12477054
World Neurosurg. 2012 Jan;77(1):130-4
pubmed: 22405392
Ultrasound Med Biol. 2012 Aug;38(8):1372-82
pubmed: 22579546
J Vis Exp. 2014 Jun 28;(88):e51278
pubmed: 24998179
Toxicol Appl Pharmacol. 2005 May 1;204(3):216-37
pubmed: 15845415
N Engl J Med. 2009 Feb 19;360(8):813-5
pubmed: 19228626
Sci Rep. 2013 Oct 04;3:2859
pubmed: 24091529
Expert Opin Drug Metab Toxicol. 2018 Sep;14(9):961-972
pubmed: 30118608
Neuro Oncol. 2015 Sep;17(9):1210-9
pubmed: 25972455
Br J Pharmacol. 2016 Feb;173(3):497-510
pubmed: 26507673
Biopharm Drug Dispos. 2012 Mar;33(2):55-71
pubmed: 22228149
Biomaterials. 2014 Mar;35(10):3406-15
pubmed: 24456605
Comb Chem High Throughput Screen. 2010 Feb;13(2):207-18
pubmed: 20053166
Int J Mol Sci. 2017 Nov 27;18(12):
pubmed: 29186899
Pharm Res. 2001 Jan;18(1):16-22
pubmed: 11336348
Neuroreport. 2000 Apr 7;11(5):1081-4
pubmed: 10790886
Lancet Neurol. 2010 Sep;9(9):906-20
pubmed: 20705518
Expert Rev Anticancer Ther. 2013 Dec;13(12):1453-61
pubmed: 24236823
Sci Rep. 2019 Jul 18;9(1):10465
pubmed: 31320671
Expert Opin Drug Deliv. 2016 Jul;13(7):963-75
pubmed: 27020469
Sci Rep. 2019 Sep 27;9(1):13957
pubmed: 31562392
Micromachines (Basel). 2019 Jun 05;10(6):
pubmed: 31195652
Cancer Lett. 1999 Nov 15;146(2):117-26
pubmed: 10656616
Leukemia. 2008 Feb;22(2):445-7
pubmed: 17690695
Exp Cell Res. 2007 Apr 15;313(7):1318-25
pubmed: 17346702
Pharmacol Res. 2008 Mar;57(3):214-22
pubmed: 18337118
Mol Pharmacol. 2013 Nov;84(5):655-69
pubmed: 24021215
Acta Neuropathol. 2018 Mar;135(3):337-361
pubmed: 29368213
Neurosurg Rev. 2017 Jan;40(1):1-14
pubmed: 27085859
Cancer Res. 1999 May 15;59(10):2411-6
pubmed: 10344751
Curr Pharm Biotechnol. 2011 Apr;12(4):656-73
pubmed: 21118088
J Neurochem. 2004 Aug;90(3):526-36
pubmed: 15255930
Eur J Nucl Med Mol Imaging. 2012 Jan;39(1):149-59
pubmed: 21983837
Drug Metab Dispos. 2014 Jul;42(7):1110-6
pubmed: 24754926
Eur J Microbiol Immunol (Bp). 2018 Jul 06;8(3):78-86
pubmed: 30345087
Biomed Pharmacother. 2018 Apr;100:335-348
pubmed: 29453043
Methods Mol Biol. 2011;686:483-98
pubmed: 21082389
J Clin Oncol. 2009 Jul 20;27(21):3503-9
pubmed: 19451444
FASEB J. 2001 Mar;15(3):719-30
pubmed: 11259390
Nat Med. 1999 Sep;5(9):1048-51
pubmed: 10470083
Surgery. 1995 Mar;117(3):334-9
pubmed: 7878541
Virchows Arch. 1994;425(2):133-8
pubmed: 7952498
Mar Drugs. 2014 Jun 27;12(7):3818-37
pubmed: 24979269
Brain Imaging Behav. 2019 Apr;13(2):354-365
pubmed: 30259405
Jpn J Cancer Res. 2001 Feb;92(2):211-9
pubmed: 11223551
Pharmaceutics. 2019 Feb 26;11(3):
pubmed: 30813646
Neurology. 1996 Sep;47(3):684-90
pubmed: 8797465
Eur J Cancer. 1996 Jun;32A(6):1070-81
pubmed: 8763349
Curr Pharm Des. 2013;19(40):7155-66
pubmed: 23909806
Pharmaceutics. 2015 Aug 03;7(3):175-87
pubmed: 26247958
Neuro Oncol. 2010 Aug;12(8):871-81
pubmed: 20511192
Drug Metab Dispos. 2007 Mar;35(3):340-4
pubmed: 17172311
Biomicrofluidics. 2015 Oct 26;9(5):054124
pubmed: 26576206
Cerebrospinal Fluid Res. 2006 Dec 21;3:13
pubmed: 17184532
Eur J Pharm Sci. 2016 Aug 25;91:98-104
pubmed: 27283486
Neuro Oncol. 2015 Mar;17 Suppl 2:ii9-ii23
pubmed: 25746091
BMC Neurosci. 2011 May 11;12:40
pubmed: 21569296
J Neuroimmunol. 2002 Oct;131(1-2):98-103
pubmed: 12458041
Curr Pharm Des. 2011;17(26):2793-802
pubmed: 21827403
Clin Cancer Res. 2007 Nov 1;13(21):6440-9
pubmed: 17975156
Acta Neuropathol. 2007 Aug;114(2):97-109
pubmed: 17618441
Int J Biol Macromol. 2018 Dec;120(Pt B):2579-2588
pubmed: 30195608
Pharmacol Res. 2009 Jun;59(6):404-13
pubmed: 19429473
J Cereb Blood Flow Metab. 2008 Jun;28(6):1222-34
pubmed: 18349876
J Histochem Cytochem. 2006 Oct;54(10):1159-67
pubmed: 16801529
Lab Invest. 2005 Jun;85(6):734-46
pubmed: 15908914
Clin Pharmacol Ther. 2015 Apr;97(4):336-46
pubmed: 25669487
Neoplasia. 2005 Apr;7(4):356-68
pubmed: 15967113
Pharm Sci Technolo Today. 1999 Jan;2(1):7-12
pubmed: 10234198
Epilepsia. 2004 May;45(5):441-51
pubmed: 15101825
Brain Res Rev. 2010 Sep 24;64(2):328-63
pubmed: 20685221
J Neurochem. 2015 Sep;134(6):1040-54
pubmed: 26112237
Neurotoxicology. 1996 Summer;17(2):481-96
pubmed: 8856743
Sci Rep. 2018 Aug 16;8(1):12272
pubmed: 30116021
Clin Pharmacol Ther. 2019 Jul;106(1):228-237
pubmed: 30673124
J Pharmacol Exp Ther. 2001 Oct;299(1):204-12
pubmed: 11561081
Expert Opin Drug Discov. 2017 Dec;12(12):1207-1218
pubmed: 28933618
Mol Pharm. 2015 Feb 2;12(2):520-32
pubmed: 25496026
J Neurochem. 2006 May;97(4):922-33
pubmed: 16573646
Methods Mol Biol. 2010;633:207-20
pubmed: 20204630
Fluids Barriers CNS. 2013 Jun 08;10(1):21
pubmed: 23758935
Mol Pharmacol. 2016 May;89(5):492-504
pubmed: 26893303
Anal Chem. 2015 Feb 3;87(3):1437-55
pubmed: 25526173
Mol Pharm. 2013 Jan 7;10(1):289-96
pubmed: 23137377
Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3900-5
pubmed: 10097135
Neuroscience. 2003;121(3):605-17
pubmed: 14568021
Int J Neuropsychopharmacol. 2014 Oct 31;18(1):
pubmed: 25539501
Vascul Pharmacol. 2002 Jun;38(6):339-48
pubmed: 12529928
Mol Pharm. 2010 Aug 2;7(4):1057-68
pubmed: 20524699
Biotechnol Adv. 2013 Dec;31(8):1397-407
pubmed: 23800690
Cancer Res. 2006 Apr 1;66(7):3355-8, discussion 3358-9
pubmed: 16585152
J Cell Physiol. 1994 Apr;159(1):101-13
pubmed: 7908023
Neuro Oncol. 2010 Jul;12(7):725-35
pubmed: 20364023
J Neurosci. 1999 Aug 1;19(15):6275-89
pubmed: 10414957
Methods Mol Biol. 2013;945:13-29
pubmed: 23097098
J Neurooncol. 2013 Jun;113(2):277-84
pubmed: 23504258
J Inherit Metab Dis. 2013 May;36(3):437-49
pubmed: 23609350
J Histochem Cytochem. 2002 Dec;50(12):1671-6
pubmed: 12486090
Drug Metab Dispos. 2003 Nov;31(11):1337-45
pubmed: 14570765
Brain Res Dev Brain Res. 1990 Oct 1;56(1):47-53
pubmed: 2279331
Rev Sci Instrum. 1982 Dec;53(12):1851-4
pubmed: 7156852
Neuroreport. 2002 Nov 15;13(16):2059-63
pubmed: 12438926
Mol Pharm. 2019 Mar 4;16(3):1312-1326
pubmed: 30721081
Drug Metab Dispos. 2020 Feb;48(2):135-145
pubmed: 31771948
Neuroscience. 2004;129(2):349-60
pubmed: 15501592
Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):3-26
pubmed: 11259830
Nature. 2014 Aug 21;512(7514):324-7
pubmed: 25043048
Clin Pharmacol Ther. 2019 May;105(5):1061-1064
pubmed: 30903694
Int J Cancer. 2002 Mar 10;98(2):173-80
pubmed: 11857404
J Natl Cancer Inst. 1991 Jan 16;83(2):105-10
pubmed: 1988684
Neuroscience. 2008 Aug 13;155(2):423-38
pubmed: 18619525
PLoS One. 2014 Feb 04;9(2):e88154
pubmed: 24505408
Mar Drugs. 2019 Jan 29;17(2):
pubmed: 30699889
Microvasc Res. 1999 Nov;58(3):312-28
pubmed: 10527772
Drug Metab Dispos. 2013 Jan;41(1):33-9
pubmed: 23014761
J Neurochem. 2005 Apr;93(2):279-89
pubmed: 15816851
Essays Biochem. 2011 Sep 7;50(1):161-78
pubmed: 21967057
Mar Drugs. 2014 Jan 22;12(1):525-46
pubmed: 24451193
J Pharm Sci. 2011 Sep;100(9):3939-50
pubmed: 21254069
J Neurosurg. 2016 Jun;124(6):1602-10
pubmed: 26566207
Drug Metab Dispos. 2018 Nov;46(11):1756-1766
pubmed: 29777024
Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9429-E9438
pubmed: 30217895
Br J Cancer. 2008 May 6;98(9):1515-24
pubmed: 18382425
Cancer Res. 2005 Dec 15;65(24):11419-28
pubmed: 16357150
Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6940-5
pubmed: 12771378
PLoS One. 2017 Jan 31;12(1):e0171048
pubmed: 28141873
Fluids Barriers CNS. 2017 Jan 23;14(1):3
pubmed: 28114946
EMBO Mol Med. 2017 Dec;9(12):1681-1695
pubmed: 29054837
N Engl J Med. 2009 Jun 25;360(26):2730-41
pubmed: 19553647
J Neurosurg. 2006 Sep;105(3):445-54
pubmed: 16961141
J Cell Physiol. 2000 Apr;183(1):108-16
pubmed: 10699972
Biochem J. 1997 Sep 1;326 ( Pt 2):539-44
pubmed: 9291129
Pharmaceuticals (Basel). 2013 Nov 25;6(12):1475-506
pubmed: 24287492
Bioorg Med Chem. 2010 Aug 1;18(15):5489-97
pubmed: 20621487
Vascul Pharmacol. 2002 Jun;38(6):349-54
pubmed: 12529929
Pharmacol Ther. 2018 Sep;189:104-122
pubmed: 29684469
Cell. 1993 Sep 24;74(6):957-67
pubmed: 8402885
Eur J Pharm Sci. 2018 Jan 15;112:168-179
pubmed: 29133240
Adv Drug Deliv Rev. 2004 Oct 14;56(12):1859-73
pubmed: 15381337
Neuro Oncol. 2003 Apr;5(2):79-88
pubmed: 12672279
PLoS One. 2013 May 01;8(5):e61359
pubmed: 23650496
J Cell Physiol. 2011 Nov;226(11):3053-63
pubmed: 21302304
Nat Biotechnol. 2018 Oct;36(9):865-874
pubmed: 30125269
J Pharm Sci. 2015 Sep;104(9):3060-8
pubmed: 25703048
Proc Natl Acad Sci U S A. 1987 Nov;84(21):7735-8
pubmed: 2444983
Cell Discov. 2017 Mar 28;3:17005
pubmed: 28377822
Curr Neuropharmacol. 2007 Mar;5(1):19-33
pubmed: 18615151
AAPS J. 2014 Sep;16(5):1046-55
pubmed: 24934296
Neuron. 2016 Jan 6;89(1):37-53
pubmed: 26687838
J Cereb Blood Flow Metab. 2016 May;36(5):862-90
pubmed: 26868179
Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H3190-7
pubmed: 17308001
Crit Rev Oncol Hematol. 2019 Sep;141:153-162
pubmed: 31302407
PLoS One. 2015 May 01;10(5):e0118638
pubmed: 25932627
Pharm Res. 2007 Jul;24(7):1262-74
pubmed: 17380269
Xenobiotica. 2008 Jul;38(7-8):833-62
pubmed: 18668432
J Neurochem. 2011 Apr;117(2):333-45
pubmed: 21291474
J Biol Chem. 2003 May 16;278(20):17664-71
pubmed: 12637526
J Neuroinflammation. 2016 Dec 12;13(1):306
pubmed: 27955696
Mol Pharm. 2018 Jul 2;15(7):2528-2538
pubmed: 29874916
PLoS One. 2012;7(5):e38149
pubmed: 22675443
Epilepsia. 2005 Jun;46(6):849-57
pubmed: 15946326
Drug Resist Updat. 2015 Mar;19:1-12
pubmed: 25791797
J Pharm Sci. 2013 Sep;102(9):3343-55
pubmed: 23650139
Cancer Res. 2005 Apr 1;65(7):2577-82
pubmed: 15805252
Biochimie. 2014 Apr;99:77-87
pubmed: 24287292
Cancer Chemother Pharmacol. 2017 Nov;80(5):881-894
pubmed: 28887666
J Neurosci Res. 2000 Jun 1;60(5):594-601
pubmed: 10820430
Neuro Oncol. 2014 Jul;16(7):896-913
pubmed: 24842956
Acta Neuropathol. 2000 Sep;100(3):323-31
pubmed: 10965803
Clin Cancer Res. 2019 Jul 1;25(13):3793-3801
pubmed: 30890548
J Neurosurg. 2015 Mar;122(3):697-706
pubmed: 25397365
Annu Rev Cell Biol. 1992;8:67-113
pubmed: 1282354
Brain Res. 2002 Dec 27;958(2):371-80
pubmed: 12470873
J Pharmacol Exp Ther. 2014 Sep;350(3):578-88
pubmed: 24947467
J Mol Graph Model. 2011 Aug;29(8):985-95
pubmed: 21571561
Int J Cancer. 2001 Jul 1;93(1):62-6
pubmed: 11391622
J Neurosurg. 2011 Sep;115(3):467-73
pubmed: 21619409
Neuroscience. 2006;138(1):159-69
pubmed: 16361063
Eur J Pharm Sci. 2018 May 30;117:68-79
pubmed: 29427702
J Neurochem. 2008 Dec;107(6):1518-28
pubmed: 19094056
Cerebrospinal Fluid Res. 2010 Aug 12;7:11
pubmed: 20704740
Neuro Oncol. 2007 Jan;9(1):20-8
pubmed: 17018695
Pharmacol Res. 2017 Sep;123:10-25
pubmed: 28634084
Onco Targets Ther. 2018 May 08;11:2673-2683
pubmed: 29780259
Nat Commun. 2018 Nov 21;9(1):4904
pubmed: 30464169
J Control Release. 2018 Dec 28;292:210-220
pubmed: 30415015
BMC Bioinformatics. 2008 Mar 18;9:153
pubmed: 18366675
Cerebrospinal Fluid Res. 2005 Oct 13;2:9
pubmed: 16223448
Genes Dev. 2001 Aug 1;15(15):1913-25
pubmed: 11485986
Nat Genet. 2000 Sep;26(1):109-13
pubmed: 10973261
Mol Cancer Ther. 2004 Dec;3(12):1577-83
pubmed: 15634651
J Neurosurg. 2017 Apr;126(4):1351-1361
pubmed: 27285538
J Neurooncol. 2016 Jul;128(3):405-15
pubmed: 26945581
Biomed Pharmacother. 2017 Dec;96:371-377
pubmed: 29028589
J Neurosurg Pediatr. 2014 Mar;13(3):276-82
pubmed: 24410126
Eur J Pharm Sci. 2013 Nov 20;50(3-4):520-5
pubmed: 23981334
J Nucl Med. 2008 Apr;49(4):649-56
pubmed: 18344435
J Lab Autom. 2015 Apr;20(2):107-26
pubmed: 25586998
Mol Pharm. 2018 Mar 5;15(3):911-922
pubmed: 29436232
Nat Commun. 2018 Jun 4;9(1):2167
pubmed: 29867199
Neurotherapeutics. 2017 Apr;14(2):284-297
pubmed: 28281173
Cell Mol Neurobiol. 2005 Feb;25(1):25-39
pubmed: 15962507
Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2076-80
pubmed: 8134351
Neuro Oncol. 2016 Jan;18(1):27-36
pubmed: 26359209
J Nucl Med. 2017 Jan;58(1):117-122
pubmed: 27493269
Drug Metab Dispos. 2013 Apr;41(4):923-31
pubmed: 23298861
Essays Biochem. 2011 Sep 7;50(1):179-207
pubmed: 21967058
Expert Opin Drug Metab Toxicol. 2016 May;12(5):499-508
pubmed: 26998936
Nat Med. 2012 Jan 26;18(4):624-9
pubmed: 22281806
Fluids Barriers CNS. 2011 Aug 25;8:23
pubmed: 21867498
J Neurochem. 1998 Aug;71(2):705-15
pubmed: 9681461
J Neurochem. 1997 Mar;68(3):1278-85
pubmed: 9048775
Tissue Barriers. 2015 Dec 15;4(1):e1129476
pubmed: 27141418
Brain Res. 2007 May 25;1147:39-50
pubmed: 17368578
J Cell Physiol. 2008 Nov;217(2):388-99
pubmed: 18543246
Mol Cancer Ther. 2016 May;15(5):819-29
pubmed: 26883271
J Proteomics. 2012 Aug 30;75(16):4999-5013
pubmed: 22842290
J Pharm Sci. 2012 Apr;101(4):1337-54
pubmed: 22213383
Biochem J. 2002 Feb 1;361(Pt 3):497-503
pubmed: 11802779
Pharm Res. 2008 Jun;25(6):1469-83
pubmed: 18219561
J Pharm Sci. 2012 Nov;101(11):4277-92
pubmed: 22864977
PLoS One. 2016 May 12;11(5):e0155013
pubmed: 27171227
Epilepsia. 2012 Nov;53 Suppl 6:1-6
pubmed: 23134489
Cancer Res. 2012 Feb 1;72(3):645-54
pubmed: 22139378
Brain Res. 2007 May 30;1150:1-13
pubmed: 17434463
Adv Drug Deliv Rev. 1999 Apr 5;36(2-3):165-178
pubmed: 10837714
Brain Res. 2009 Aug 11;1284:12-21
pubmed: 19501061
Neurosurg Focus. 2015 Mar;38(3):E8
pubmed: 25727230
In Vitro. 1981 Apr;17(4):353-62
pubmed: 6263791
Front Cell Neurosci. 2019 Aug 28;13:396
pubmed: 31555096
Nat Commun. 2019 Jun 13;10(1):2621
pubmed: 31197168
Circ J. 2009 Nov;73(11):1983-92
pubmed: 19801852
J Neurochem. 2002 Aug;82(3):716-9
pubmed: 12153495
NeuroRx. 2005 Jan;2(1):15-26
pubmed: 15717054
Exp Brain Res. 2017 Jun;235(6):1749-1758
pubmed: 28285405
Nucl Med Biol. 2003 Oct;30(7):747-51
pubmed: 14499333
Nature. 2003 Oct 30;425(6961):917-25
pubmed: 14586460
Nucl Med Biol. 2016 Mar;43(3):191-7
pubmed: 26924499
Biochim Biophys Acta. 1976 Nov 11;455(1):152-62
pubmed: 990323
Drug Discov Today. 2014 Oct;19(10):1563-71
pubmed: 24929222
J Nucl Med. 2019 Apr;60(4):486-491
pubmed: 30237210
BMC Mol Biol. 2009 Jul 03;10:68
pubmed: 19575803
Anticancer Agents Med Chem. 2012 Oct 1;12(8):880-90
pubmed: 22583399
Pharm Res. 2000 Oct;17(10):1198-205
pubmed: 11145224
Clin Pharmacol Ther. 2005 Jun;77(6):503-14
pubmed: 15961982
Nat Protoc. 2010 Jul;5(7):1265-72
pubmed: 20595955
Curr Pharm Des. 2004;10(12):1295-312
pubmed: 15134482
Nat Biotechnol. 2012 Aug;30(8):783-91
pubmed: 22729031
Science. 1980 Feb 8;207(4431):653-5
pubmed: 6101511
J Neurooncol. 2018 Nov;140(2):269-279
pubmed: 30128689
Biochim Biophys Acta Proteins Proteom. 2017 Jul;1865(7):875-890
pubmed: 27890679
Brain Res. 1997 Oct 17;771(2):329-42
pubmed: 9401753
Drug Metab Dispos. 2010 Jun;38(6):917-22
pubmed: 20212014
Cell. 2007 Nov 30;131(5):861-72
pubmed: 18035408
Brain Pathol. 2009 Jan;19(1):132-43
pubmed: 19076778
Br J Pharmacol. 2010 Jul;160(6):1453-63
pubmed: 20590635
Lancet Oncol. 2002 Jul;3(7):397-406
pubmed: 12142169
J Clin Invest. 1979 Aug;64(2):684-8
pubmed: 457877
Curr Protoc Pharmacol. 2013 Oct 08;62:7.15.1-7.15.30
pubmed: 24510719
Sci Rep. 2017 Oct 17;7(1):13393
pubmed: 29042617
Mol Pharm. 2011 Aug 1;8(4):1332-41
pubmed: 21707071
Neurosurgery. 2019 Jun 21;:
pubmed: 31225627
Drug Resist Updat. 2015 Jan;18:1-17
pubmed: 25554624
Neurosurgery. 1999 Apr;44(4):732-40; discussion 740-1
pubmed: 10201297
Curr Cancer Drug Targets. 2006 Aug;6(5):433-45
pubmed: 16918310
Brain Res. 2012 Oct 15;1479:17-30
pubmed: 22940232
Expert Opin Drug Metab Toxicol. 2010 Oct;6(10):1161-74
pubmed: 20843279
Cell Mol Neurobiol. 2010 Mar;30(2):247-53
pubmed: 19728078
Clin Neuropathol. 1997 Jan-Feb;16(1):34-6
pubmed: 9020393
Biochim Biophys Acta. 2013 Aug;1836(1):158-65
pubmed: 23618720
Sci Rep. 2019 Nov 5;9(1):16310
pubmed: 31690750
Brain Res. 2013 Jul 12;1521:1-15
pubmed: 22789905
Brain Res. 2007 Feb 23;1134(1):1-11
pubmed: 17196184
Cancer Res. 2000 Jan 1;60(1):47-50
pubmed: 10646850
J Nucl Med. 2015 Dec;56(12):1930-6
pubmed: 26359257
Drug Metab Dispos. 2016 Dec;44(12):1881-1889
pubmed: 27638506
J Control Release. 2016 Mar 10;225:217-29
pubmed: 26809004
J Neurosci Methods. 2019 Apr 15;318:17-33
pubmed: 30797797
J Cereb Blood Flow Metab. 2008 Aug;28(8):1449-59
pubmed: 18446168
J Cereb Blood Flow Metab. 2008 Feb;28(2):312-28
pubmed: 17609686
Exp Cell Res. 1992 Apr;199(2):330-40
pubmed: 1347502
Cancer Res. 2003 May 15;63(10):2409-15
pubmed: 12750260
BMC Cancer. 2010 Sep 01;10:468
pubmed: 20809959
J Nucl Med. 2013 Aug;54(8):1181-7
pubmed: 23833270
N Engl J Med. 2009 Feb 19;360(8):765-73
pubmed: 19228619
Nature. 2005 Sep 15;437(7057):426-31
pubmed: 16163360
Drug Metab Dispos. 2019 Apr;47(4):405-411
pubmed: 30683809
Glia. 2012 May;60(6):882-93
pubmed: 22392649
Neuro Oncol. 2018 Jan 22;20(2):184-191
pubmed: 29016900
Brain Tumor Pathol. 2016 Apr;33(2):89-96
pubmed: 26920424
J Pharmacol Exp Ther. 2011 Nov;339(2):579-88
pubmed: 21828264
AAPS J. 2013 Oct;15(4):913-32
pubmed: 23784110
Eukaryot Cell. 2009 Nov;8(11):1803-7
pubmed: 19767445
Sci Rep. 2015 Aug 03;5:12670
pubmed: 26234720
Acta Neuropathol. 2016 Jun;131(6):803-20
pubmed: 27157931
Lancet. 1995 Apr 22;345(8956):1008-12
pubmed: 7723496
Toxicol In Vitro. 2008 Apr;22(3):799-811
pubmed: 18280105
J Biomech Eng. 1981 Aug;103(3):177-85
pubmed: 7278196
Arterioscler Thromb Vasc Biol. 1998 May;18(5):677-85
pubmed: 9598824
Am J Physiol. 1984 Sep;247(3 Pt 2):H484-93
pubmed: 6476141
J Pharm Biomed Anal. 2019 Feb 5;164:496-508
pubmed: 30453156
Handb Clin Neurol. 2016;134:3-18
pubmed: 26948345
Cancer Lett. 2007 Aug 28;254(1):11-29
pubmed: 17275180
PLoS One. 2016 Sep 22;11(9):e0163180
pubmed: 27658243
Brain Res. 2003 May 9;971(2):221-31
pubmed: 12706238
J Cereb Blood Flow Metab. 2012 Nov;32(11):2002-11
pubmed: 22828996
Neuroscience. 2011 Mar 17;177:23-34
pubmed: 21195136
J Neurooncol. 2002 Mar;57(1):27-36
pubmed: 12125964
J Neurochem. 2012 Nov;123(4):491-503
pubmed: 22845665
J Biol Chem. 2000 Sep 29;275(39):30069-74
pubmed: 10893247
ACS Chem Neurosci. 2013 Feb 20;4(2):225-37
pubmed: 23421673
Nat Rev Drug Discov. 2007 Aug;6(8):650-61
pubmed: 17667956
BMC Neurosci. 2011 Jan 07;12:4
pubmed: 21214926
J Oncol. 2019 Jul 22;2019:9342796
pubmed: 31428153
Lancet Neurol. 2019 Apr;18(4):376-393
pubmed: 30797715
Am J Pathol. 2012 Oct;181(4):1126-41
pubmed: 22858156
J Clin Invest. 2000 Feb;105(3):279-85
pubmed: 10675353
J Colloid Interface Sci. 2016 Nov 15;482:142-150
pubmed: 27501037
Arch Med Res. 2014 Nov;45(8):730-7
pubmed: 25446619
Nucl Med Biol. 2013 Oct;40(7):873-8
pubmed: 23845421
Eur J Med Chem. 2008 Aug;43(8):1581-92
pubmed: 18206268
Curr Pharm Des. 2014;20(10):1450-62
pubmed: 23789951
PLoS One. 2014 Jun 17;9(6):e99733
pubmed: 24936790
Exp Biol Med (Maywood). 2017 Nov;242(17):1669-1678
pubmed: 28195514
Fluids Barriers CNS. 2013 Mar 26;10(1):16
pubmed: 23531482
J Cereb Blood Flow Metab. 2011 Dec;31(12):2267-81
pubmed: 21792245
Int J Pharm. 2012 Apr 15;426(1-2):193-201
pubmed: 22274587
NeuroRx. 2005 Jan;2(1):73-85
pubmed: 15717059
Histochem Cell Biol. 2015 Dec;144(6):597-611
pubmed: 26449856
J Neurochem. 2015 Sep;134(6):1104-15
pubmed: 25951748