The Mitotic Apparatus and Kinetochores in Microcephaly and Neurodevelopmental Diseases.
chromosome segregation
kinetochore
microcephaly
mitotic apparatus
neural progenitors
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
24 12 2019
24 12 2019
Historique:
received:
20
11
2019
revised:
18
12
2019
accepted:
21
12
2019
entrez:
28
12
2019
pubmed:
28
12
2019
medline:
17
9
2020
Statut:
epublish
Résumé
Regulators of mitotic division, when dysfunctional or expressed in a deregulated manner (over- or underexpressed) in somatic cells, cause chromosome instability, which is a predisposing condition to cancer that is associated with unrestricted proliferation. Genes encoding mitotic regulators are growingly implicated in neurodevelopmental diseases. Here, we briefly summarize existing knowledge on how microcephaly-related mitotic genes operate in the control of chromosome segregation during mitosis in somatic cells, with a special focus on the role of kinetochore factors. Then, we review evidence implicating mitotic apparatus- and kinetochore-resident factors in the origin of congenital microcephaly. We discuss data emerging from these works, which suggest a critical role of correct mitotic division in controlling neuronal cell proliferation and shaping the architecture of the central nervous system.
Identifiants
pubmed: 31878213
pii: cells9010049
doi: 10.3390/cells9010049
pmc: PMC7016623
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Regione Lazio
ID : 85-2017-15348
Pays : International
Organisme : PRIN-MIUR
ID : 2017FNZRN3_005
Pays : International
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