Exploiting RAS Nucleotide Cycling as a Strategy for Drugging RAS-Driven Cancers.

Animals Antineoplastic Agents / therapeutic use Humans Neoplasms / drug therapy Proto-Oncogene Proteins p21(ras) / genetics Signal Transduction / drug effects ras Proteins / genetics
cell signaling/guanine nucleotide binding proteins and effectors drug mechanisms drug targets/oncoprotein and tumor suppressor drug targets oncogenes and tumor suppressors/KRAS

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
24 Dec 2019
Historique:
received: 06 12 2019
revised: 20 12 2019
accepted: 20 12 2019
entrez: 28 12 2019
pubmed: 28 12 2019
medline: 19 5 2020
Statut: epublish

Résumé

Oncogenic mutations in

Identifiants

DOI: 10.3390/ijms21010141 PMID: 31878223 PMC: PMC6982188
pubmed: 31878223
pii: ijms21010141
doi: 10.3390/ijms21010141
pmc: PMC6982188
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Proto-Oncogene Proteins p21(ras) EC 3.6.5.2
ras Proteins EC 3.6.5.2

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NCI NIH HHS
ID : R01CA131378
Pays : United States
Organisme : NCI NIH HHS
ID : R01CA148817
Pays : United States
Organisme : NCI NIH HHS
ID : R01CA197147
Pays : United States
Organisme : NCI NIH HHS
ID : R01CA155638
Pays : United States

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Auteurs

Tyler E Mattox (TE)

Drug Discovery Research Center, University of South Alabama Mitchell Cancer Institute, Mobile, AL 36604, USA.
ORCID: 0000-0002-8323-0535

Xi Chen (X)

Drug Discovery Research Center, University of South Alabama Mitchell Cancer Institute, Mobile, AL 36604, USA.
ADT Pharmaceuticals, Orange Beach, AL 36561, USA.

Yulia Y Maxuitenko (YY)

Drug Discovery Research Center, University of South Alabama Mitchell Cancer Institute, Mobile, AL 36604, USA.

Adam B Keeton (AB)

Drug Discovery Research Center, University of South Alabama Mitchell Cancer Institute, Mobile, AL 36604, USA.
ADT Pharmaceuticals, Orange Beach, AL 36561, USA.

Gary A Piazza (GA)

Drug Discovery Research Center, University of South Alabama Mitchell Cancer Institute, Mobile, AL 36604, USA.
ADT Pharmaceuticals, Orange Beach, AL 36561, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Exploiting RAS Nucleotide Cycling as a...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Exploiting RAS Nucleotide Cycling as a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Exploiting RAS Nucleotide Cycling as a...
questionsmedicales.fr › Tumeurs › Exploiting RAS Nucleotide Cycling as a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes p21(ras) › Exploiting RAS Nucleotide Cycling as a...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Exploiting RAS Nucleotide Cycling as a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G ras › Exploiting RAS Nucleotide Cycling as a...