Modeling Resilience to Damage in Multiple Sclerosis: Plasticity Meets Connectivity.
brain networks
connectivity
inflammation
long-term potentiation (LTP)
multiple sclerosis
resting state functional MRI (rs-fMRI)
synaptic plasticity
synaptic scaling
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Dec 2019
24 Dec 2019
Historique:
received:
31
10
2019
revised:
05
12
2019
accepted:
20
12
2019
entrez:
28
12
2019
pubmed:
28
12
2019
medline:
19
5
2020
Statut:
epublish
Résumé
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelinating white matter lesions and neurodegeneration, with a variable clinical course. Brain network architecture provides efficient information processing and resilience to damage. The peculiar organization characterized by a low number of highly connected nodes (hubs) confers high resistance to random damage. Anti-homeostatic synaptic plasticity, in particular long-term potentiation (LTP), represents one of the main physiological mechanisms underlying clinical recovery after brain damage. Different types of synaptic plasticity, including both anti-homeostatic and homeostatic mechanisms (synaptic scaling), contribute to shape brain networks. In MS, altered synaptic functioning induced by inflammatory mediators may represent a further cause of brain network collapse in addition to demyelination and grey matter atrophy. We propose that impaired LTP expression and pathologically enhanced upscaling may contribute to disrupting brain network topology in MS, weakening resilience to damage and negatively influencing the disease course.
Identifiants
pubmed: 31878257
pii: ijms21010143
doi: 10.3390/ijms21010143
pmc: PMC6981966
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fondazione Italiana Sclerosi Multipla
ID : 2019/S/1
Organisme : Ministero della Salute
ID : Ricerca Corrente
Organisme : undefined <span style="color:gray;font-size:10px;">undefined</span>
ID : 5 × 1000 grant to IRCCS Neuromed
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