RNA Sequencing of Collecting Duct Renal Cell Carcinoma Suggests an Interaction between miRNA and Target Genes and a Predominance of Deregulated Solute Carrier Genes.
RNA sequencing
collecting duct carcinoma
solute carrier proteins
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
24 Dec 2019
24 Dec 2019
Historique:
received:
28
11
2019
revised:
19
12
2019
accepted:
22
12
2019
entrez:
28
12
2019
pubmed:
28
12
2019
medline:
28
12
2019
Statut:
epublish
Résumé
Collecting duct carcinoma (CDC) is a rare renal cell carcinoma subtype with a very poor prognosis. There have been only a few studies on gene expression analysis in CDCs. We compared the gene expression profiles of two CDC cases with those of eight normal tissues of renal cell carcinoma patients. At a threshold of |log2fold-change| ≥ 1, 3349 genes were upregulated and 1947 genes were downregulated in CDCs compared to the normal samples. Pathway analysis of the deregulated genes revealed that cancer pathways and cell cycle pathways were most prominent in CDCs. The most upregulated gene was
Identifiants
pubmed: 31878355
pii: cancers12010064
doi: 10.3390/cancers12010064
pmc: PMC7017122
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : the Johannes und Frieda Marohn-Stiftung
ID : 00 not given
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Amino Acids. 2012 Jan;42(1):171-9
pubmed: 21369940
Can Urol Assoc J. 2015 Sep-Oct;9(9-10):E589-93
pubmed: 26425219
J Biol Chem. 1999 Apr 23;274(17):11455-8
pubmed: 10206947
Curr Oncol. 2019 Apr;26(2):e175-e179
pubmed: 31043824
Mol Genet Genomic Med. 2019 May;7(5):e607
pubmed: 30793530
Oncotarget. 2016 May 24;7(21):29901-15
pubmed: 27144525
Clin Cancer Res. 2017 Apr 15;23(8):2105-2115
pubmed: 27663598
Int J Biochem Cell Biol. 2013 Sep;45(9):2007-11
pubmed: 23831838
Br J Biomed Sci. 2000;57(2):170-8
pubmed: 10912295
Nature. 2006 May 18;441(7091):362-5
pubmed: 16710422
Nucleic Acids Res. 2018 Jan 4;46(D1):D1062-D1067
pubmed: 29165669
Elife. 2015 Aug 12;4:
pubmed: 26267216
BMC Cancer. 2017 Jan 4;17(1):9
pubmed: 28052770
J Biol Chem. 1992 Sep 25;267(27):19724-9
pubmed: 1527093
Eur Urol. 2016 Sep;70(3):516-21
pubmed: 26149668
Mol Cancer Res. 2019 Jan;17(1):84-96
pubmed: 30131446
Nature. 2016 Mar 24;531(7595):528-32
pubmed: 26982719
BMC Bioinformatics. 2013 Apr 15;14:128
pubmed: 23586463
Genome Biol. 2014;15(12):550
pubmed: 25516281
J Oral Pathol Med. 2008 Apr;37(4):211-20
pubmed: 18205743
N Engl J Med. 1986 Dec 25;315(26):1650-9
pubmed: 3537791
Int J Urol. 2019 Sep;26(9):868-877
pubmed: 31183903
Nucleic Acids Res. 2018 Jan 4;46(D1):D296-D302
pubmed: 29126174
Sci Rep. 2016 Aug 03;6:30988
pubmed: 27484008
Aging (Albany NY). 2016 Oct 26;8(10):2260-2261
pubmed: 27783564
Cancer Treat Rev. 2019 Sep;79:101891
pubmed: 31491662
Nat Protoc. 2008;3(6):1101-8
pubmed: 18546601
Urology. 1979 Mar;13(3):315-7
pubmed: 442358
Biochem J. 2011 Jan 15;433(2):383-91
pubmed: 21029045
Expert Rev Anticancer Ther. 2013 Jun;13(6):711-9
pubmed: 23773105
Cell Rep. 2018 Jun 19;23(12):3698
pubmed: 29925010
Nucleic Acids Res. 2014 Jan;42(Database issue):D92-7
pubmed: 24297251
Cell Rep. 2015 Jul 7;12(1):116-127
pubmed: 26119730
Acta Pharm Sin B. 2015 Sep;5(5):378-89
pubmed: 26579469
Nucleic Acids Res. 2016 Jan 4;44(D1):D481-7
pubmed: 26656494
Bioinformatics. 2016 Sep 15;32(18):2847-9
pubmed: 27207943
Mol Cancer. 2016 Feb 02;15:10
pubmed: 26831905
PLoS One. 2016 Aug 11;11(8):e0161163
pubmed: 27512993
Cancer. 1976 Dec;38(6):2469-80
pubmed: 1000477
J Cancer Res Clin Oncol. 2017 Jun;143(6):961-970
pubmed: 28260162
Nucleic Acids Res. 2016 Jan 4;44(D1):D457-62
pubmed: 26476454
J Biol Chem. 2019 Nov 15;294(46):17593-17602
pubmed: 31554661
Aktuelle Urol. 2019 Dec;50(6):606-611
pubmed: 31486060
Nucleic Acids Res. 2016 Jan 4;44(D1):D488-94
pubmed: 26481357
Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13895-900
pubmed: 11717447
Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17923-8
pubmed: 16330770
J Cell Biochem. 2019 Apr;120(4):6046-6056
pubmed: 30520096