Risperidone-induced retrograde ejaculation and lurasidone may be the alternative.
Antipsychotic
lurasidone
retrograde ejaculation
risperidone
sexual dysfunction
Journal
Industrial psychiatry journal
ISSN: 0972-6748
Titre abrégé: Ind Psychiatry J
Pays: India
ID NLM: 101547239
Informations de publication
Date de publication:
Historique:
received:
14
01
2019
accepted:
19
08
2019
entrez:
28
12
2019
pubmed:
28
12
2019
medline:
28
12
2019
Statut:
ppublish
Résumé
Medication adherence with antipsychotics is adversely impacted by the burden of untoward adverse effects. In particular, sexual side effects are often underreported by patients, which may interfere with drug compliance. Presented here is the case of a 35-year-old male with schizophrenia, previously treated with risperidone following which he developed sexual dysfunction and hence was stopped. He was admitted to our psychiatric inpatient ward after a second psychotic exacerbation of the disorder after being drug free for about 6 months. On admission, treatment with risperidone was restarted, following which he developed retrograde ejaculation on oral risperidone therapy at a dose of 8 mg/day, with resolution of symptoms after cross tapering risperidone with lurasidone. Pharmacological interventions that may reduce antipsychotic-induced sexual dysfunction include changing the type of medication and administering other medications that are known to improve sexual dysfunction. This case emphasizes the need for routine inquiry into sexual dysfunction during atypical antipsychotic therapy.
Identifiants
pubmed: 31879463
doi: 10.4103/ipj.ipj_8_19
pii: IPJ-28-152
pmc: PMC6929214
doi:
Types de publication
Case Reports
Langues
eng
Pagination
152-154Informations de copyright
Copyright: © 2019 Industrial Psychiatry Journal.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
Transl Androl Urol. 2016 Aug;5(4):592-601
pubmed: 27652230
Int Clin Psychopharmacol. 2004 Mar;19(2):111-2
pubmed: 15076020
Arch Gen Psychiatry. 2000 Nov;57(11):1012-30
pubmed: 11074867
J Am Acad Child Adolesc Psychiatry. 2002 Apr;41(4):365-6
pubmed: 11931591
J Clin Psychiatry. 1996 Nov;57(11):549-50
pubmed: 8968309
Br J Pharmacol. 2007 Oct;152(3):332-40
pubmed: 17603545
Am J Psychiatry. 1976 Jan;133(1):82-5
pubmed: 1247127