Pleiotropic actions of allopregnanolone underlie therapeutic benefits in stress-related disease.
Allopregnanolone
CRF
GABAergic transmission
Pregnenolone
Progesterone
Toll-like receptors
Journal
Neurobiology of stress
ISSN: 2352-2895
Titre abrégé: Neurobiol Stress
Pays: United States
ID NLM: 101643409
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
03
10
2019
revised:
15
11
2019
accepted:
21
11
2019
entrez:
28
12
2019
pubmed:
28
12
2019
medline:
28
12
2019
Statut:
epublish
Résumé
For several years, research from around the world has suggested that the neuroactive steroid (3α,5α)-3-hydroxypregnan-20-one (allopregnanolone) may have therapeutic potential for treatment of various stress-related diseases including post-traumatic stress disorder (PTSD), depression, alcohol use disorders (AUDs), as well as neurological and psychiatric conditions that are worsened in the presence of stress, such as multiple sclerosis, schizophrenia, and seizure disorders. In this review, we make the argument that the pleiotropic actions of allopregnanolone account for its ability to promote recovery in such a wide variety of illnesses. Likewise, the allopregnanolone precursors, pregnenolone and progesterone, share many actions of allopregnanolone. Of course, pregnenolone and progesterone lack direct effects on GABA
Identifiants
pubmed: 31879693
doi: 10.1016/j.ynstr.2019.100203
pii: S2352-2895(19)30055-4
pii: 100203
pmc: PMC6920111
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100203Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA024095
Pays : United States
Informations de copyright
© 2019 The Authors.
Déclaration de conflit d'intérêts
All other authors report no conflict of interest.
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