Towards standardization of absolute SPECT/CT quantification: a multi-center and multi-vendor phantom study.

SPECT/CT absolute quantification performance evaluation recovery coefficient

Journal

EJNMMI physics
ISSN: 2197-7364
Titre abrégé: EJNMMI Phys
Pays: Germany
ID NLM: 101658952

Informations de publication

Date de publication:
26 Dec 2019
Historique:
received: 26 08 2019
accepted: 05 12 2019
entrez: 28 12 2019
pubmed: 28 12 2019
medline: 28 12 2019
Statut: epublish

Résumé

Absolute quantification of radiotracer distribution using SPECT/CT imaging is of great importance for dosimetry aimed at personalized radionuclide precision treatment. However, its accuracy depends on many factors. Using phantom measurements, this multi-vendor and multi-center study evaluates the quantitative accuracy and inter-system variability of various SPECT/CT systems as well as the effect of patient size, processing software and reconstruction algorithms on recovery coefficients (RC). Five SPECT/CT systems were included: Discovery™ NM/CT 670 Pro (GE Healthcare), Precedence™ 6 (Philips Healthcare), Symbia Intevo™, and Symbia™ T16 (twice) (Siemens Healthineers). Three phantoms were used based on the NEMA IEC body phantom without lung insert simulating body mass indexes (BMI) of 25, 28, and 47 kg/m RC decreased with decreasing sphere diameter for each system. Inter-system variability (MAD) was 16 and 17% for RC Absolute SPECT quantification in a multi-center and multi-vendor setting is feasible, especially when reconstruction protocols are standardized, paving the way for a standard for absolute quantitative SPECT.

Identifiants

pubmed: 31879813
doi: 10.1186/s40658-019-0268-5
pii: 10.1186/s40658-019-0268-5
pmc: PMC6933042
doi:

Types de publication

Journal Article

Langues

eng

Pagination

29

Subventions

Organisme : FP7/2007-2013
ID : 602812

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Auteurs

Steffie M B Peters (SMB)

Department of Radiology and Nuclear Medicine, Radboudumc, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands. steffie.peters@radboudumc.nl.

Niels R van der Werf (NR)

Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Department of Medical Physics, Albert Schweitzer Hospital, Dordrecht, The Netherlands.

Marcel Segbers (M)

Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.

Floris H P van Velden (FHP)

Department of Radiology, Section of Medical Physics, Leiden University Medical Center, Leiden, The Netherlands.

Roel Wierts (R)

Department of Radiology and Nuclear Medicine, Maastricht UMC+, Maastricht, The Netherlands.

Koos J A K Blokland (KJAK)

Department of Radiology, Section of Medical Physics, Leiden University Medical Center, Leiden, The Netherlands.

Mark W Konijnenberg (MW)

Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.

Sergiy V Lazarenko (SV)

Department of Nuclear Medicine, Noordwest Ziekenhuisgroep, Alkmaar, The Netherlands.

Eric P Visser (EP)

Department of Radiology and Nuclear Medicine, Radboudumc, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

Martin Gotthardt (M)

Department of Radiology and Nuclear Medicine, Radboudumc, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

Classifications MeSH