Highly Mesoporous Metal-Organic Frameworks as Synergistic Multimodal Catalytic Platforms for Divergent Cascade Reactions.

cascade reactions heterogeneous catalysis mesoporous MOFs multimodal catalysts nanocatalysts

Journal

Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543

Informations de publication

Date de publication:
24 02 2020
Historique:
received: 26 12 2019
pubmed: 28 12 2019
medline: 28 12 2019
entrez: 28 12 2019
Statut: ppublish

Résumé

Rational engineering and assimilation of diverse chemo- and biocatalytic functionalities in a single nanostructure is highly desired for efficient multistep chemical reactions but has so far remained elusive. Here, we design and synthesize multimodal catalytic nanoreactors (MCNRs) based on a mesoporous metal-organic framework (MOF). The MCNRs consist of customizable metal nanocrystals and stably anchored enzymes in the mesopores, as well as coordinatively unsaturated cationic metal MOF nodes, all within a single nanoreactor space. The highly intimate and diverse catalytic mesoporous microenvironments and facile accessibility to the active site in the MCNR enables the cooperative and synergistic participation from different chemo- and biocatalytic components. This was shown by one-pot multistep cascade reactions involving a heterogeneous catalytic nitroaldol reaction followed by a [Pd/lipase]-catalyzed chemoenzymatic dynamic kinetic resolution to yield optically pure (>99 % ee) nitroalcohol derivatives in quantitative yields.

Identifiants

pubmed: 31880381
doi: 10.1002/anie.201916578
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3416-3422

Informations de copyright

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Auteurs

Soumen Dutta (S)

Center for Nanospace-confined Chemical Reactions (NCCR), Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.
Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.

Nitee Kumari (N)

Center for Nanospace-confined Chemical Reactions (NCCR), Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.
Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.

Sateesh Dubbu (S)

Center for Nanospace-confined Chemical Reactions (NCCR), Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.
Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.

Sun Woo Jang (SW)

Center for Nanospace-confined Chemical Reactions (NCCR), Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.
Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.

Amit Kumar (A)

Center for Nanospace-confined Chemical Reactions (NCCR), Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.
Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.

Hiroyoshi Ohtsu (H)

Department of Chemistry, School of Science, Tokyo Institute of Technology, Tokyo, 152-8550, Japan.

Junghoon Kim (J)

Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.

Seung Hwan Cho (SH)

Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.

Masaki Kawano (M)

Department of Chemistry, School of Science, Tokyo Institute of Technology, Tokyo, 152-8550, Japan.

In Su Lee (IS)

Center for Nanospace-confined Chemical Reactions (NCCR), Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.
Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, 37673, South Korea.

Classifications MeSH