Interleukin-8 Predicts Fatigue at 12 Months Post-Injury in Children with Traumatic Brain Injury.

Adolescent Biomarkers / blood Brain Injuries, Traumatic / blood Child Child, Preschool Fatigue / blood Female Follow-Up Studies Humans Infant Interleukin-8 / blood Male Predictive Value of Tests Prospective Studies Time Factors
Glasgow Coma Scale children fatigue serum biomarkers traumatic brain injury

Journal

Journal of neurotrauma
ISSN: 1557-9042
Titre abrégé: J Neurotrauma
Pays: United States
ID NLM: 8811626

Informations de publication

Date de publication:
15 04 2021
Historique:
pubmed: 28 12 2019
medline: 14 1 2022
entrez: 28 12 2019
Statut: ppublish

Résumé

Despite many children experiencing fatigue after childhood brain injury, little is known about the predictors of this complaint. To date, traditional indices of traumatic brain injury (TBI) severity have not predicted reliably persisting fatigue (up to three years post-injury). This study aimed to establish whether persisting fatigue is predicted by serum biomarker concentrations in child TBI. We examined whether acute serum biomarker expression would improve prediction models of 12-month fatigue based on injury severity. Blood samples were collected from 87 children (1-17 years at injury) sustaining mild to severe TBI (Glasgow Coma Scale [GCS] range 3-15; mean 12.43; classified as mild TBI [

Identifiants

DOI: 10.1089/neu.2018.6083 PMID: 31880977
pubmed: 31880977
doi: 10.1089/neu.2018.6083
doi:

Substances chimiques

Biomarkers 0
Interleukin-8 0

Types de publication

Journal Article Multicenter Study Observational Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1151-1163

Auteurs

Alison Crichton (A)

Murdoch Children's Research Institute, Melbourne, Australia.
Monash University Faculty of Medicine Nursing and Health Sciences, School of Clinical Sciences, The Department of Paediatrics, School of Clinical Sciences, Monash University, Melbourne, Australia.

Vera Ignjatovic (V)

Murdoch Children's Research Institute, Melbourne, Australia.
Department of Paediatrics, University of Melbourne, Melbourne, Australia.

Franz E Babl (FE)

Murdoch Children's Research Institute, Melbourne, Australia.
Department of Paediatrics, University of Melbourne, Melbourne, Australia.
Royal Children's Hospital, Melbourne, Australia.

Ed Oakley (E)

Murdoch Children's Research Institute, Melbourne, Australia.
Department of Paediatrics, University of Melbourne, Melbourne, Australia.
Royal Children's Hospital, Melbourne, Australia.

Mardee Greenham (M)

Murdoch Children's Research Institute, Melbourne, Australia.
School of Psychological Sciences, University of Melbourne, Melbourne, Australia.

Stephen Hearps (S)

Murdoch Children's Research Institute, Melbourne, Australia.

Carmel Delzoppo (C)

Murdoch Children's Research Institute, Melbourne, Australia.
Royal Children's Hospital, Melbourne, Australia.

Miriam H Beauchamp (MH)

Department of Psychology, University of Montreal, Montreal, Canada.
Research Center, Ste-Justine Hospital, Montreal, Canada.

Anne-Marie Guerguerian (AM)

Critical Care Medicine, The Hospital for Sick Children (SickKids), Toronto, Canada.
Neuroscience and Mental Health Research Program, The Hospital for Sick Children Research Institute, Toronto, Canada.
The Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada.

Kathy Boutis (K)

Paediatric Emergency Medicine, The Hospital for Sick Children (SickKids), Toronto, Canada.
Department of Paediatrics, University of Toronto, Toronto, Canada.

Evyatar Hubara (E)

Critical Care Medicine, The Hospital for Sick Children (SickKids), Toronto, Canada.

Jamie Hutchison (J)

Critical Care Medicine, The Hospital for Sick Children (SickKids), Toronto, Canada.
Neuroscience and Mental Health Research Program, The Hospital for Sick Children Research Institute, Toronto, Canada.
The Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada.

Vicki Anderson (V)

Murdoch Children's Research Institute, Melbourne, Australia.
School of Psychological Sciences, University of Melbourne, Melbourne, Australia.
Royal Children's Hospital, Melbourne, Australia.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Interleukin-8 Predicts Fatigue at 12 Months...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Interleukin-8 Predicts Fatigue at 12 Months...
questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Traumatismes cranioencéphaliques › Lésions encéphaliques › Lésions traumatiques de l'encéphale › Interleukin-8 Predicts Fatigue at 12 Months...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Interleukin-8 Predicts Fatigue at 12 Months...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Interleukin-8 Predicts Fatigue at 12 Months...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Fatigue › Interleukin-8 Predicts Fatigue at 12 Months...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études de suivi › Interleukin-8 Predicts Fatigue at 12 Months...
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questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Interleukin-8 Predicts Fatigue at 12 Months...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-8 › Interleukin-8 Predicts Fatigue at 12 Months...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Valeur prédictive des tests › Interleukin-8 Predicts Fatigue at 12 Months...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Interleukin-8 Predicts Fatigue at 12 Months...
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