Novel fucoidan based bioactive targeted nanoparticles from Undaria Pinnatifida for treatment of pancreatic cancer.
Antineoplastic Agents, Phytogenic
/ chemistry
Apoptosis
/ drug effects
Cell Line, Tumor
Cell Movement
/ drug effects
Cell Proliferation
/ drug effects
Humans
Lactoferrin
/ chemistry
Nanoparticles
/ chemistry
Phaeophyceae
/ chemistry
Polyelectrolytes
/ chemistry
Polysaccharides
/ chemistry
Static Electricity
Undaria
/ chemistry
Fucoidan
Lactoferrin
Pancreatic cancer
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
15 Feb 2020
15 Feb 2020
Historique:
received:
03
10
2019
revised:
16
12
2019
accepted:
20
12
2019
pubmed:
28
12
2019
medline:
21
11
2020
entrez:
28
12
2019
Statut:
ppublish
Résumé
Fucoidan is a marine polymer extracted from diverse types of brown algae. This polysaccharide showed great potential towards treatment of different types of cancer. In this study, the activity of fucoidan extracted from Undaria Pinnatifida was investigated against pancreatic cancer (one of the most life-threatening cancers). Then, in an attempt to enhance the polymer's activity against cancer cells, conversion the polymer solution to nanoparticles was suggested to enhance its delivery through pancreatic cancer surrounding stroma. Novel fucoidan based nanoparticles were elaborated by polyelectrolyte interaction with the positively charged, active targeting ligand lactoferrin. The formulation was optimized through the interplay between different factors. Effect of fucoidan solution along with its blank nanoparticles was tested on the viability of pancreatic cancer cells and its migration and invasion abilities. Results confirmed the cytotoxic ability of fucoidan against pancreatic cancer. IC
Identifiants
pubmed: 31881303
pii: S0141-8130(19)37974-7
doi: 10.1016/j.ijbiomac.2019.12.177
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Polyelectrolytes
0
Polysaccharides
0
fucoidan
9072-19-9
Lactoferrin
EC 3.4.21.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
390-401Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.