Neutrophil extracellular traps (NETs) formation induced by TGF-β in oral lichen planus - Possible implications for the development of oral cancer.
Flavonoids
Lipopolysaccharide
Oral lichen planus
Oral squamous cell carcinoma
Polymorphonuclear neutrophils
Transforming growth factor - beta
Journal
Immunobiology
ISSN: 1878-3279
Titre abrégé: Immunobiology
Pays: Netherlands
ID NLM: 8002742
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
05
09
2019
revised:
17
12
2019
accepted:
17
12
2019
pubmed:
29
12
2019
medline:
25
5
2021
entrez:
29
12
2019
Statut:
ppublish
Résumé
Oral Potentially Malignant Disorders (OPMDs) including Oral Lichen Planus (OLP) are associated with risk of transformation to oral squamous cell carcinoma (OSCC). Available data show that innate immune cells involving polymorphonuclear neutrophils (PMNs) with their ability to neutrophil extracellular traps (NETs) formation are likely to be directly involved in development of cancer. Examination of NETs generation by TGF-β - induced neutrophils of OLP patients showed increased amounts of traps with MPO, H3Cit and cfDNA, known to be released with NETs. The presence of excessive amounts of NETs components may lead to numerous adverse consequences associated with potential transformation to OSCC. Bacterial-related infection may enhance the NETs formation and lead to consequences resulting from the excessive number of individual elements of these networks. It is likely that regulating NETs release by the flavonoids presented herein may be beneficial not only for inhibiting OLP development, but also in reducing risk of transformation to OSCC.
Identifiants
pubmed: 31882256
pii: S0171-2985(19)30297-9
doi: 10.1016/j.imbio.2019.151901
pii:
doi:
Substances chimiques
Transforming Growth Factor beta
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
151901Informations de copyright
Copyright © 2019. Published by Elsevier GmbH.