Model-driven neuromodulation of the right posterior region promotes encoding of long-term memories.
EEG
Facial memory
Long-term memory
Parietal cortex
Theta rhythm
fMRI
tACS
Journal
Brain stimulation
ISSN: 1876-4754
Titre abrégé: Brain Stimul
Pays: United States
ID NLM: 101465726
Informations de publication
Date de publication:
Historique:
received:
27
06
2019
revised:
21
11
2019
accepted:
16
12
2019
pubmed:
29
12
2019
medline:
25
8
2020
entrez:
29
12
2019
Statut:
ppublish
Résumé
Long-term recognition memory depends both on initial encoding and on subsequent recognition processes. In this study we aimed at improving long-term memory by modulating posterior parietal brain activity during the encoding process. If this area is causally involved in memory encoding, its facilitation should lead to behavioral improvement. Based on the dual-process memory framework, we also expected that the neuromodulation would dissociate subsequent familiarity-based and recollection-based recognition. We investigated the role of the posterior parietal brain oscillations in facial memory formation in three separate experiments using electroencephalography (EEG), functional magnetic resonance imaging (fMRI), and model-driven, multi-electrode transcranial alternating current stimulation (tACS). Using fMRI and EEG, we confirmed that the right posterior parietal cortex is an essential node that promotes the encoding of long-term memories. We found that single-trial low theta power in this region predicts subsequent long-term recognition. On this basis, we fine-tuned the spatial and frequency settings of tACS during memory encoding. Model-driven tACS over the right posterior brain area augmented subsequent long-term recognition memory and particularly the familiarity of the observed stimuli. The recollection process, and short-term task performance as control remained unchanged. Control stimulation over the left hemisphere had no behavioral effect. We conclude that the right posterior brain area is crucial in long-term memory encoding.
Sections du résumé
BACKGROUND
Long-term recognition memory depends both on initial encoding and on subsequent recognition processes.
OBJECTIVE
In this study we aimed at improving long-term memory by modulating posterior parietal brain activity during the encoding process. If this area is causally involved in memory encoding, its facilitation should lead to behavioral improvement. Based on the dual-process memory framework, we also expected that the neuromodulation would dissociate subsequent familiarity-based and recollection-based recognition.
METHODS
We investigated the role of the posterior parietal brain oscillations in facial memory formation in three separate experiments using electroencephalography (EEG), functional magnetic resonance imaging (fMRI), and model-driven, multi-electrode transcranial alternating current stimulation (tACS).
RESULTS
Using fMRI and EEG, we confirmed that the right posterior parietal cortex is an essential node that promotes the encoding of long-term memories. We found that single-trial low theta power in this region predicts subsequent long-term recognition. On this basis, we fine-tuned the spatial and frequency settings of tACS during memory encoding. Model-driven tACS over the right posterior brain area augmented subsequent long-term recognition memory and particularly the familiarity of the observed stimuli. The recollection process, and short-term task performance as control remained unchanged. Control stimulation over the left hemisphere had no behavioral effect.
CONCLUSION
We conclude that the right posterior brain area is crucial in long-term memory encoding.
Identifiants
pubmed: 31882373
pii: S1935-861X(19)30490-5
doi: 10.1016/j.brs.2019.12.019
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
474-483Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.