Dichotomic effects of clinically used drugs on tumor growth, bone remodeling and pain management.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
27 12 2019
27 12 2019
Historique:
received:
10
04
2019
accepted:
12
12
2019
entrez:
29
12
2019
pubmed:
29
12
2019
medline:
29
12
2019
Statut:
epublish
Résumé
Improvements in the survival of breast cancer patients have led to the emergence of bone health and pain management as key aspects of patient's quality of life. Here, we used a female rat MRMT-1 model of breast cancer-induced bone pain to compare the effects of three drugs used clinically morphine, nabilone and zoledronate on tumor progression, bone remodeling and pain relief. We found that chronic morphine reduced the mechanical hypersensitivity induced by the proliferation of the luminal B aggressive breast cancer cells in the tumor-bearing femur and prevented spinal neuronal and astrocyte activation. Using MTT cell viability assay and MRI coupled to
Identifiants
pubmed: 31882872
doi: 10.1038/s41598-019-56622-5
pii: 10.1038/s41598-019-56622-5
pmc: PMC6934511
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20155Subventions
Organisme : Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada)
ID : 353649
Pays : International
Commentaires et corrections
Type : ErratumIn
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