A natural polymorphism in Zika virus NS2A protein responsible of virulence in mice.
Amino Acid Substitution
Animals
Apoptosis
Cell Line
Disease Models, Animal
Female
Genome, Viral
Genomics
/ methods
Host-Pathogen Interactions
Immunity, Innate
Mice
Polymorphism, Genetic
Viral Nonstructural Proteins
/ genetics
Virulence
/ genetics
Virus Replication
Zika Virus
/ physiology
Zika Virus Infection
/ immunology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
27 12 2019
27 12 2019
Historique:
received:
25
06
2019
accepted:
05
12
2019
entrez:
29
12
2019
pubmed:
29
12
2019
medline:
18
11
2020
Statut:
epublish
Résumé
Zika virus (ZIKV) infection is currently one of the major concerns in human public health due to its association with neurological disorders. Intensive effort has been implemented for the treatment of ZIKV, however there are not currently approved vaccines or antivirals available to combat ZIKV infection. In this sense, the identification of virulence factors associated with changes in ZIKV virulence could help to develop safe and effective countermeasures to treat ZIKV or to prevent future outbreaks. Here, we have compared the virulence of two related ZIKV strains from the recent outbreak in Brazil (2015), Rio Grande do Norte Natal (RGN) and Paraiba. In spite of both viruses being identified in the same period of time and region, significant differences in virulence and replication were observed using a validated mouse model of ZIKV infection. While ZIKV-RGN has a 50% mouse lethal dose (MLD
Identifiants
pubmed: 31882898
doi: 10.1038/s41598-019-56291-4
pii: 10.1038/s41598-019-56291-4
pmc: PMC6934710
doi:
Substances chimiques
Viral Nonstructural Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19968Subventions
Organisme : NIAID NIH HHS
ID : R21 AI130500
Pays : United States
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