Quality of life trajectories during the first three years after diagnosis of breast cancer: the NEON-BC study.
breast neoplasms
cluster analysis
patient-reported outcome measures
quality of life
Journal
Journal of public health (Oxford, England)
ISSN: 1741-3850
Titre abrégé: J Public Health (Oxf)
Pays: England
ID NLM: 101188638
Informations de publication
Date de publication:
22 09 2021
22 09 2021
Historique:
pubmed:
29
12
2019
medline:
25
2
2023
entrez:
29
12
2019
Statut:
ppublish
Résumé
We aimed to identify and characterize quality of life trajectories up to 3 years after breast cancer diagnosis. A total of 460 patients were evaluated at baseline (before treatments), and after 1- and 3-years. Patient-reported outcomes, including quality of life (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30, QLQ-C30), anxiety, depression and sleep quality, were assessed in all evaluations. Model-based clustering was used to identify quality of life trajectories. We identified four trajectories without intersection during 3 years. The two trajectories characterized by better quality of life depicted relatively stable scores; in the other trajectories, quality of life worsened until 1 year, though in one of them the score at 3 years improved. Sociodemographic and clinical characteristics at baseline did not differ between trajectories, except for mastectomy, which was higher in the worst trajectory. Anxiety, depression and poor sleep quality increased from the best to the worst trajectory. The type of surgery and the variation of other patient-reported outcomes were associated with the course of quality of life over 3 years. More research to understand the heterogeneity of individual trajectories within these major patterns of variation is needed.
Sections du résumé
BACKGROUND
We aimed to identify and characterize quality of life trajectories up to 3 years after breast cancer diagnosis.
METHODS
A total of 460 patients were evaluated at baseline (before treatments), and after 1- and 3-years. Patient-reported outcomes, including quality of life (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30, QLQ-C30), anxiety, depression and sleep quality, were assessed in all evaluations. Model-based clustering was used to identify quality of life trajectories.
RESULTS
We identified four trajectories without intersection during 3 years. The two trajectories characterized by better quality of life depicted relatively stable scores; in the other trajectories, quality of life worsened until 1 year, though in one of them the score at 3 years improved. Sociodemographic and clinical characteristics at baseline did not differ between trajectories, except for mastectomy, which was higher in the worst trajectory. Anxiety, depression and poor sleep quality increased from the best to the worst trajectory.
CONCLUSIONS
The type of surgery and the variation of other patient-reported outcomes were associated with the course of quality of life over 3 years. More research to understand the heterogeneity of individual trajectories within these major patterns of variation is needed.
Identifiants
pubmed: 31883015
pii: 5688175
doi: 10.1093/pubmed/fdz159
doi:
Substances chimiques
Neon
4VB4Y46AHD
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
521-531Subventions
Organisme : FEDER
Organisme : Operational Programme Competitiveness and Internationalization and national
Organisme : Foundation for Science and Technology
ID : POCI-01-0145-FEDER-016867
Organisme : Unidade de Investigação em Epidemiologia-Instituto de Saúde Pública da Universidade do Porto
ID : POCI-01-0145-FEDER-006862
Organisme : NEON-PC - Neuro-oncological complications of prostate cancer: longitudinal study of cognitive decline
ID : POCI01-0145-FEDER-032358
Organisme : NA
ID : SFRH/BD/119390/2016
Organisme : FF
ID : SFRH/BD/92630/2013
Organisme : FCT
Organisme : Programa Operacional Capital Humano
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.