Methionine and methionine sulfoxide induces neurochemical and morphological changes in cultured astrocytes: Involvement of Na

Acetylcholinesterase / metabolism Adenosine Triphosphate / metabolism Animals Astrocytes / drug effects Cells, Cultured Methionine / analogs & derivatives Oxidative Stress / drug effects Rats, Wistar Signal Transduction / drug effects Sodium-Potassium-Exchanging ATPase / metabolism
Acetylcholinesterase Astrocytes Hypermethioninemia Na(+),K (+)-ATPase Oxidative status Purinergic signaling

Journal

Neurotoxicology
ISSN: 1872-9711
Titre abrégé: Neurotoxicology
Pays: Netherlands
ID NLM: 7905589

Informations de publication

Date de publication:
03 2020
Historique:
received: 01 08 2019
revised: 18 12 2019
accepted: 21 12 2019
pubmed: 29 12 2019
medline: 23 1 2021
entrez: 29 12 2019
Statut: ppublish

Résumé

Hypermethioninemia is an inherited metabolic disorder characterized by high concentration of methionine (Met) and its metabolites such as methionine sulfoxide (Met-SO), which may lead to development of neurological alterations. The aim of this study was to investigate the in vitro effects of Met or Met-SO on viability, proliferation, morphology, and neurochemical parameters in primary culture of cortical astrocytes, after treatment with 1 or 2 mM Met or 0.5 mM Met-SO, for 24, 48, and 72 h. Met or Met-SO did not affect cell viability and proliferation but induced astrocyte hypertrophy. Acetylcholinesterase activity was increased, while Na

Identifiants

DOI: 10.1016/j.neuro.2019.12.013 PMID: 31883448
pubmed: 31883448
pii: S0161-813X(19)30150-0
doi: 10.1016/j.neuro.2019.12.013
pii:
doi:

Substances chimiques

Adenosine Triphosphate 8L70Q75FXE
Methionine AE28F7PNPL
Acetylcholinesterase EC 3.1.1.7
Sodium-Potassium-Exchanging ATPase EC 7.2.2.13
methionine sulfoxide XN1XVI4B2C

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

60-70

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest All authors declare that they have no conflicts of interest.

Auteurs

Mayara Sandrielly Pereira Soares (MSP)

Programa de Pós-Graduação em Bioquímica e Bioprospecção - Laboratório de Neuroquímica, Inflamação e Câncer, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário S/N, Pelotas, RS, Brazil. Electronic address: mspereirasoares@gmail.com.

Nathalia Stark Pedra (NS)

Programa de Pós-Graduação em Bioquímica e Bioprospecção - Laboratório de Neuroquímica, Inflamação e Câncer, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário S/N, Pelotas, RS, Brazil.

Natália Pontes Bona (NP)

Programa de Pós-Graduação em Bioquímica e Bioprospecção - Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário S/N, Pelotas, RS, Brazil.

Anita Ávila de Souza (AÁ)

Programa de Pós-Graduação em Bioquímica e Bioprospecção - Laboratório de Neuroquímica, Inflamação e Câncer, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário S/N, Pelotas, RS, Brazil.

Fernanda Cardoso Teixeira (FC)

Programa de Pós-Graduação em Bioquímica e Bioprospecção - Laboratório de Neuroquímica, Inflamação e Câncer, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário S/N, Pelotas, RS, Brazil.

Juliana Hofstatter Azambuja (JH)

Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.

Angela Ts Wyse (AT)

Laboratório de Neuroproteção e Doença Metabólica, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Elizandra Braganhol (E)

Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.

Francieli Moro Stefanello (FM)

Programa de Pós-Graduação em Bioquímica e Bioprospecção - Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário S/N, Pelotas, RS, Brazil.

Roselia Maria Spanevello (RM)

Programa de Pós-Graduação em Bioquímica e Bioprospecção - Laboratório de Neuroquímica, Inflamação e Câncer, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário S/N, Pelotas, RS, Brazil.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › Methionine and methionine sulfoxide induces...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Methionine and methionine sulfoxide induces...
questionsmedicales.fr › Eucaryotes › Animaux › Methionine and methionine sulfoxide induces...
questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Methionine and methionine sulfoxide induces...
questionsmedicales.fr › Cellules › Cellules cultivées › Methionine and methionine sulfoxide induces...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Méthionine › Methionine and methionine sulfoxide induces...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Methionine and methionine sulfoxide induces...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › Methionine and methionine sulfoxide induces...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Methionine and methionine sulfoxide induces...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › P-type ATPases › Sodium-Potassium-Exchanging ATPase › Methionine and methionine sulfoxide induces...