Bioinformatics of excretory/secretory proteins of Toxoplasma gondii strain ME49.

Computational Biology Humans Protozoan Proteins / chemistry Toxoplasma / chemistry Toxoplasmosis / parasitology
Abundance of Antigenic Regions (AAR) Bioinformatics analysis Drugs Excretory/secretory proteins Toxoplasma gondii Toxoplasmosis Vaccines

Journal

Microbial pathogenesis
ISSN: 1096-1208
Titre abrégé: Microb Pathog
Pays: England
ID NLM: 8606191

Informations de publication

Date de publication:
Mar 2020
Historique:
received: 06 08 2019
revised: 23 12 2019
accepted: 23 12 2019
pubmed: 29 12 2019
medline: 13 11 2020
entrez: 29 12 2019
Statut: ppublish

Résumé

Toxoplasma gondii is an obligate intracellular parasite that is globally distributed and can infect almost all warm-blooded animals, including humans. While vaccines are not available for prophylaxis, there are limited therapeutic options which often do not result in eradication of parasites from patients. ME49 is a cystogenic strain of T. gondii with a potential as a vaccine candidate. Excretory and secretory (ES) proteins are thought to play crucial roles in host-parasite interactions. Hence, we predicted and functionally annotated the ES proteins in T. gondii ME49 using public databases. ES proteins were further examined for the characteristics and possible functions through gene ontology (GO) term enrichment and analyses of metabolic pathways, enzyme code distribution (EC distributing) and protein domains. The potential antigenicity of T. gondii ME49 ES proteins was evaluated for the first time using Abundance of Antigenic Regions (AAR) value to predict the antigenic potential by measuring sequence length and number of antigenic regions. The results showed that the ES proteins have different AAR values at RNA and microarray level. Our studies provide valuable information for future experimental studies, including the identification of novel ES proteins of therapeutic, diagnostic and immunoprophylactic interests.

Identifiants

DOI: 10.1016/j.micpath.2019.103951 PMID: 31883450
pubmed: 31883450
pii: S0882-4010(19)31414-7
doi: 10.1016/j.micpath.2019.103951
pii:
doi:

Substances chimiques

Protozoan Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

103951

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no competing financial interests and non-financial interests.

Auteurs

Zhenrong Ma (Z)

Department of Parasitology, Xiangya School of Basic Medicine, Central South University, Changsha, China. Electronic address: 176511073@csu.edu.cn.

Alaa Majeed Mutashar Alhameed (AM)

Department of Parasitology, Xiangya School of Basic Medicine, Central South University, Changsha, China; Laboratory Department, Thi Qar Refai Health Office, Iraqi Ministry of Health, Refai, Iraq. Electronic address: alaaalhameedy@yahoo.come.

Atipatsa Chiwanda Kaminga (AC)

Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China; Department of Mathematics, Mzuzu University, Mzuzu, Malawi. Electronic address: atipatsachiwanda@yahoo.com.uk.

Bin Lu (B)

Department of Parasitology, Xiangya School of Basic Medicine, Central South University, Changsha, China. Electronic address: 2366109554@qq.com.

Xuanwu Li (X)

Department of Parasitology, Xiangya School of Basic Medicine, Central South University, Changsha, China. Electronic address: 1049933494@qq.com.

Jie Zhang (J)

Department of Parasitology, Xiangya School of Basic Medicine, Central South University, Changsha, China. Electronic address: 15121000@qq.com.

Xiang Wu (X)

Department of Parasitology, Xiangya School of Basic Medicine, Central South University, Changsha, China. Electronic address: wxspring@126.com.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Informatique › Biologie informatique › Bioinformatics of excretory/secretory proteins...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Bioinformatics of excretory/secretory proteins...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de protozoaire › Bioinformatics of excretory/secretory proteins...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Coccidia › Eimeriida › Sarcocystidae › Toxoplasma › Bioinformatics of excretory/secretory proteins...
questionsmedicales.fr › Infection › Maladies parasitaires › Protozooses › Coccidiose › Toxoplasmose › Bioinformatics of excretory/secretory proteins...