Synthesis and antitumor activities investigation of a C-nucleoside analogue of ribavirin.
Antitumor activity
C-nucleoside
Ovarian cancer
Ribavirin
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
15 Feb 2020
15 Feb 2020
Historique:
received:
25
11
2019
revised:
09
12
2019
accepted:
21
12
2019
pubmed:
29
12
2019
medline:
18
2
2020
entrez:
29
12
2019
Statut:
ppublish
Résumé
SRO-91 is a non-natural ribofuranosyl-1,2,3-triazole C-nucleoside obtained by a synthetic sequence involving a C-alkynyl glycosylation mediated by metallic indium and a Huisgen cycloaddition for the construction of the triazole. Its structure is close to the one of ribavirin, a drug presenting a broad-spectrum against viral infections. SRO-91 antitumor activities were investigated on 9 strains of tumor cells and IC
Identifiants
pubmed: 31883488
pii: S0223-5234(19)31166-3
doi: 10.1016/j.ejmech.2019.112009
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Ribavirin
49717AWG6K
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112009Informations de copyright
Copyright © 2019 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.