Successful Prediction of Human Pharmacokinetics After Oral Administration by Optimized Physiologically Based Pharmacokinetics Approach and Permeation Assay Using Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Cells.
absorption
absorption, distribution, metabolism, and excretion (ADME)
intestinal absorption
pharmacokinetics
physiologically based pharmacokinetic (PBPK) modeling
Journal
Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
23
10
2019
revised:
16
12
2019
accepted:
18
12
2019
pubmed:
31
12
2019
medline:
22
6
2021
entrez:
30
12
2019
Statut:
ppublish
Résumé
None of the physiologically based pharmacokinetic (PBPK) approaches using preclinical data show high predictability of human pharmacokinetic (PK) profiles for drugs affected by the intestinal first-pass effect. Here we report a novel PBPK approach that incorporated the findings of a permeation study using human induced pluripotent stem cell-derived intestinal epithelial cells (hiPSC-IECs) to predict human PK profiles after oral administration of drugs. In hiPSC-IECs, gene expression levels of cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp) are enhanced by rifampicin and 1,25-dihydroxyvitamin D
Identifiants
pubmed: 31884012
pii: S0022-3549(19)30865-2
doi: 10.1016/j.xphs.2019.12.019
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1605-1614Informations de copyright
Copyright © 2020 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.