Dodelates A-E: Five dimeric eudesmane sesquiterpenoids from Dobinea delavayi.
Animals
Antimalarials
/ chemistry
Crystallography, X-Ray
Dose-Response Relationship, Drug
Malaria
/ drug therapy
Mice
Mice, Inbred Strains
Models, Molecular
Molecular Structure
Parasitic Sensitivity Tests
Plant Roots
/ chemistry
Plants, Medicinal
/ chemistry
Plasmodium yoelii
/ drug effects
Sapindaceae
/ chemistry
Sesquiterpenes, Eudesmane
/ chemistry
Structure-Activity Relationship
Anacardiaceae
Antimalarial activity
Dimeric eudesmane sesquiterpenoids
Dobinea delavayi
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
10
11
2019
revised:
28
11
2019
accepted:
28
11
2019
pubmed:
31
12
2019
medline:
2
3
2021
entrez:
30
12
2019
Statut:
ppublish
Résumé
Dodelates A-E (1-5), five angeloylated eudesmane sesquiterpenoid dimers were isolated from the roots of Dobinea delavayi. Their structures were elucidated by extensive spectroscopic data and single-crystal X-ray diffraction analyses. A possible biosynthetic pathway of these five compounds was proposed. Compounds 1 and 3 exhibited moderate antimalarial activities against Plasmodium yoelii BY265RFP.
Identifiants
pubmed: 31884146
pii: S0045-2068(19)31913-3
doi: 10.1016/j.bioorg.2019.103488
pii:
doi:
Substances chimiques
Antimalarials
0
Sesquiterpenes, Eudesmane
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103488Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.