Third Ventricle Width Assessed by Transcranial Sonography as Predictor of Long-Term Cognitive Impairment.
Aged
Aged, 80 and over
Cognitive Dysfunction
/ diagnostic imaging
Cohort Studies
Female
Follow-Up Studies
Humans
Longitudinal Studies
Male
Middle Aged
Neuropsychological Tests
Prospective Studies
Psychomotor Performance
Substantia Nigra
/ diagnostic imaging
Third Ventricle
/ diagnostic imaging
Ultrasonography, Doppler, Transcranial
/ methods
Cognitive decline
dementia
sonography
third ventricle
transcranial
Journal
Journal of Alzheimer's disease : JAD
ISSN: 1875-8908
Titre abrégé: J Alzheimers Dis
Pays: Netherlands
ID NLM: 9814863
Informations de publication
Date de publication:
2020
2020
Historique:
pubmed:
31
12
2019
medline:
20
11
2020
entrez:
30
12
2019
Statut:
ppublish
Résumé
Non-invasive biomarkers of cognitive impairment are needed. We aim to evaluate transcranial sonographic markers as predictors of cognitive impairment in a prospective cohort. To study the changes in the third ventricle diameter and the SN echogenicity between the baseline and the control visit, as well as its association with cognitive performance and the diagnosis of cognitive impairment in a prospective cohort. From the longitudinal population-based Asymptomatic Intracranial Atherosclerosis Study, we selected those subjects that received a complete transcranial sonography (TCS) and extensive cognitive testing, both at baseline and follow-up. We evaluated third ventricle (IIIv) width, echogenicity of substantia nigra (SN), and temporal changes of these parameters. We included 289 participants with a median follow-up time of 7.16 years. Those subjects who developed cognitive decline (n = 23, 7.96%) had a larger IIIv at baseline than those who did not (0.54±0.14 cm versus 0.41±0.15 cm; p = 0.001). A cut-off point of 0.465 cm for the IIIv width was identified as an independent predictor of long-term cognitive impairment after adjustment for age, gender, educational level, and vascular risk score. Change in IIIv diameter after follow-up was not associated with diagnosis of cognitive impairment. The area of SN and the presence of hyperechogenicity of the SN remained stable over time and was not associated with the diagnosis of cognitive impairment. IIIv width assessed by TCS emerged as an independent predictor of long-term cognitive impairment.
Sections du résumé
BACKGROUND
Non-invasive biomarkers of cognitive impairment are needed. We aim to evaluate transcranial sonographic markers as predictors of cognitive impairment in a prospective cohort.
OBJECTIVE
To study the changes in the third ventricle diameter and the SN echogenicity between the baseline and the control visit, as well as its association with cognitive performance and the diagnosis of cognitive impairment in a prospective cohort.
METHODS
From the longitudinal population-based Asymptomatic Intracranial Atherosclerosis Study, we selected those subjects that received a complete transcranial sonography (TCS) and extensive cognitive testing, both at baseline and follow-up. We evaluated third ventricle (IIIv) width, echogenicity of substantia nigra (SN), and temporal changes of these parameters.
RESULTS
We included 289 participants with a median follow-up time of 7.16 years. Those subjects who developed cognitive decline (n = 23, 7.96%) had a larger IIIv at baseline than those who did not (0.54±0.14 cm versus 0.41±0.15 cm; p = 0.001). A cut-off point of 0.465 cm for the IIIv width was identified as an independent predictor of long-term cognitive impairment after adjustment for age, gender, educational level, and vascular risk score. Change in IIIv diameter after follow-up was not associated with diagnosis of cognitive impairment. The area of SN and the presence of hyperechogenicity of the SN remained stable over time and was not associated with the diagnosis of cognitive impairment.
CONCLUSION
IIIv width assessed by TCS emerged as an independent predictor of long-term cognitive impairment.
Identifiants
pubmed: 31884478
pii: JAD190949
doi: 10.3233/JAD-190949
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM