Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.
aging
bone marrow
cxcl12-abudant reticular cells
endothelial cells
niche
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
05 02 2020
05 02 2020
Historique:
received:
08
02
2019
revised:
14
11
2019
accepted:
22
11
2019
pubmed:
31
12
2019
medline:
28
4
2021
entrez:
31
12
2019
Statut:
ppublish
Résumé
While intrinsic changes in aging hematopoietic stem cells (HSCs) are well characterized, it remains unclear how extrinsic factors affect HSC aging. Here, we demonstrate that cells in the niche-endothelial cells (ECs) and CXCL12-abundant reticular cells (CARs)-highly express the heme-degrading enzyme, heme oxygenase 1 (HO-1), but then decrease its expression with age. HO-1-deficient animals (HO-1
Identifiants
pubmed: 31885181
doi: 10.15252/embr.201947895
pmc: PMC7001511
doi:
Substances chimiques
Heme Oxygenase-1
EC 1.14.14.18
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e47895Subventions
Organisme : Ministerstwo Nauki i Szkolnictwa Wyższego (MNiSW)
Pays : International
Organisme : Narodowe Centrum Nauki (NCN)
ID : NCN2015/18/M/NZ3/00387 2017/25/N/NZ1/02156
Pays : International
Organisme : Narodowe Centrum Nauki (NCN)
ID : NCN2013/11/N/NZ3/00956
Pays : International
Organisme : PL-Grid Infrastructure
Pays : International
Organisme : NHLBI NIH HHS
ID : F30 HL147460
Pays : United States
Informations de copyright
© 2019 The Authors. Published under the terms of the CC BY 4.0 license.
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