Bretschneider (Custodiol®) and St. Thomas 2 Cardioplegia Solution in Mitral Valve Repair via Anterolateral Right Thoracotomy: A Propensity-Modelled Comparison.
Aged
Cardiac Surgical Procedures
/ adverse effects
Cardioplegic Solutions
/ adverse effects
Confidence Intervals
Female
Glucose
/ adverse effects
Heart
/ drug effects
Humans
Male
Mannitol
/ adverse effects
Middle Aged
Mitral Valve
/ drug effects
Myocardial Ischemia
/ metabolism
Myocardium
/ metabolism
Potassium Chloride
/ adverse effects
Procaine
/ adverse effects
Thoracotomy
/ methods
Journal
Mediators of inflammation
ISSN: 1466-1861
Titre abrégé: Mediators Inflamm
Pays: United States
ID NLM: 9209001
Informations de publication
Date de publication:
2019
2019
Historique:
received:
30
08
2019
accepted:
12
11
2019
entrez:
31
12
2019
pubmed:
31
12
2019
medline:
9
6
2020
Statut:
epublish
Résumé
Single-dose cardioplegia is preferred in minimal invasive mitral valve surgery to maintain the adjustment of the operative site without change of preset visualization. The aim of our study was to compare two widely used crystalloid cardioplegias Bretschneider (Custodiol®) versus St. Thomas 2 in patients who underwent mitral valve repair via small anterolateral right thoracotomy. From May 2012 until February 2019, 184 isolated mitral valve procedures for mitral valve repair via anterolateral right thoracotomy were performed using Bretschneider (Custodiol®) cardioplegia ( Peak hs-cTnT was higher after use of Bretschneider (Custodiol®) (geometric mean 716 mg/L, 95% confidence interval (CI) 605-847 mg/L) vs. St. Thomas 2 (561 mg/L, CI 467-674 mg/L, Use of St. Thomas 2 cardioplegia was associated with lower postoperative peak levels of all cardiac markers that reflect cardiac ischemia such as hs-cTnT, CK, and CK-MB as compared to Bretschneider (Custodiol®) in propensity-weighted treatment groups.
Sections du résumé
BACKGROUND
BACKGROUND
Single-dose cardioplegia is preferred in minimal invasive mitral valve surgery to maintain the adjustment of the operative site without change of preset visualization. The aim of our study was to compare two widely used crystalloid cardioplegias Bretschneider (Custodiol®) versus St. Thomas 2 in patients who underwent mitral valve repair via small anterolateral right thoracotomy.
MATERIAL AND METHODS
METHODS
From May 2012 until February 2019, 184 isolated mitral valve procedures for mitral valve repair via anterolateral right thoracotomy were performed using Bretschneider (Custodiol®) cardioplegia (
RESULTS
RESULTS
Peak hs-cTnT was higher after use of Bretschneider (Custodiol®) (geometric mean 716 mg/L, 95% confidence interval (CI) 605-847 mg/L) vs. St. Thomas 2 (561 mg/L, CI 467-674 mg/L,
CONCLUSION
CONCLUSIONS
Use of St. Thomas 2 cardioplegia was associated with lower postoperative peak levels of all cardiac markers that reflect cardiac ischemia such as hs-cTnT, CK, and CK-MB as compared to Bretschneider (Custodiol®) in propensity-weighted treatment groups.
Identifiants
pubmed: 31885497
doi: 10.1155/2019/5648051
pmc: PMC6914981
doi:
Substances chimiques
Bretschneider cardioplegic solution
0
Cardioplegic Solutions
0
Mannitol
3OWL53L36A
Procaine
4Z8Y51M438
Potassium Chloride
660YQ98I10
Glucose
IY9XDZ35W2
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5648051Informations de copyright
Copyright © 2019 Constantin Mork et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
Références
PeerJ. 2018 May 28;6:e4810
pubmed: 29868261
Thorac Cardiovasc Surg. 1980 Oct;28(5):295-302
pubmed: 6161427
Thorac Cardiovasc Surg. 1984 Oct;32(5):271-6
pubmed: 6083614
Artif Organs. 2017 May;41(5):470-475
pubmed: 27878830
Eur Heart J. 2017 Sep 21;38(36):2739-2791
pubmed: 28886619
Bioelectrochemistry. 2019 Feb;125:58-69
pubmed: 30265864
Ann Thorac Surg. 1996 Jan;61(1):67-75
pubmed: 8561641
Heart Lung Circ. 2014 Sep;23(9):863-8
pubmed: 24767979
Innovations (Phila). 2016 Nov/Dec;11(6):420-424
pubmed: 27879532
Eur J Cardiothorac Surg. 2016 Nov;50(5):787-791
pubmed: 27369117
Thorac Cardiovasc Surg. 2016 Jan;64(1):53-8
pubmed: 26600405
Thorac Cardiovasc Surg. 1988 Jun;36(3):151-6
pubmed: 3145585
Heart. 2019 May;105(10):783-789
pubmed: 30541760