RNA Expression Profile and Alternative Splicing Signatures of Genistein-Treated Breeder Hens Revealed by Hepatic Transcriptomic Analysis.
Alternative Splicing
/ drug effects
Animals
Antioxidants
/ metabolism
Chickens
Cysteine-Rich Protein 61
/ genetics
Dietary Supplements
Genistein
/ pharmacology
Liver
/ drug effects
RNA
/ metabolism
RNA, Long Noncoding
/ metabolism
Transcriptome
/ drug effects
Triglycerides
/ blood
Xedar Receptor
/ genetics
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2019
2019
Historique:
received:
01
08
2019
accepted:
11
10
2019
entrez:
31
12
2019
pubmed:
31
12
2019
medline:
2
5
2020
Statut:
epublish
Résumé
Little information has been available about the influence of dietary genistein (GEN) on hepatic transcriptome of laying broiler breeder (LBB) hens. The study is aimed at broadening the understanding of RNA expression profiles and alternative splicing (AS) signatures of GEN-treated breeder hens and thereby improving laying performance and immune function of hens during the late egg-laying period. 720 LBB hens were randomly allocated into three groups with supplemental dietary GEN doses (0, 40 mg/kg, and 400 mg/kg). Each treatment has 8 replicates of 30 birds. Dietary GEN enhanced the antioxidative capability of livers, along with the increased activities of glutathione peroxidase and catalase. Furthermore, it improved lipid metabolic status and apoptotic process in the liver of hens. 40 mg/kg dietary GEN had the better effects on improving immune function and laying performance. However, transcriptome data indicated that 400 mg/kg dietary GEN did negative regulation of hormone biosynthetic process. Also, it upregulated the expressions of EDA2R and CYR61 by the Cis regulation of neighbouring genes (lncRNA_XLOC_018890 and XLOC_024242), which might activate NF-
Identifiants
pubmed: 31885785
doi: 10.1155/2019/3829342
pmc: PMC6899279
doi:
Substances chimiques
Antioxidants
0
Cysteine-Rich Protein 61
0
RNA, Long Noncoding
0
Triglycerides
0
Xedar Receptor
0
RNA
63231-63-0
Genistein
DH2M523P0H
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3829342Informations de copyright
Copyright © 2019 Zengpeng Lv et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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