Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome.
Journal
Case reports in endocrinology
ISSN: 2090-6501
Titre abrégé: Case Rep Endocrinol
Pays: United States
ID NLM: 101576457
Informations de publication
Date de publication:
2019
2019
Historique:
received:
08
08
2019
revised:
22
09
2019
accepted:
04
10
2019
entrez:
31
12
2019
pubmed:
31
12
2019
medline:
31
12
2019
Statut:
epublish
Résumé
Medullary thyroid cancer (MTC) is a rare form of neoplasm affecting the thyroid gland. This neuroendocrine tumor is capable of releasing active substances causing systemic manifestation in the form of flushing, diarrhea, and uncommonly, Ectopic Cushing's syndrome (ECS). MTC can be hereditary as a part of multiple endocrine neoplasm type 2 syndrome (MEN2) or arise sporadically. We report a case of a 74-year-old female presenting with chronic diarrhea, in whom diagnosis of sporadic MTC was delayed due to previous history of gastrointestinal (GI) disturbances. The patient developed liver metastases yielding ACTH dependent Cushing's Syndrome leading to abnormal clinical presentation and laboratory values driven by elevated cortisol level. Metastatic MTC should be considered in patients presenting with chronic diarrhea and weakness unexplained by other GI related causes.
Identifiants
pubmed: 31885947
doi: 10.1155/2019/6414921
pmc: PMC6925804
doi:
Types de publication
Case Reports
Langues
eng
Pagination
6414921Informations de copyright
Copyright © 2019 Aleksandra I. Pivovarova et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
Références
Hormones (Athens). 2008 Jul-Sep;7(3):259-62
pubmed: 18694866
J Clin Endocrinol Metab. 2011 Sep;96(9):2796-804
pubmed: 21752886
Thyroid. 2006 Nov;16(11):1163-70
pubmed: 17123344
J Clin Endocrinol Metab. 2009 Sep;94(9):3121-31
pubmed: 19734443
J Investig Med High Impact Case Rep. 2016 Apr 08;4(2):2324709616643989
pubmed: 27141514
J Clin Oncol. 2012 Jan 10;30(2):134-41
pubmed: 22025146
J Clin Endocrinol Metab. 2000 Feb;85(2):919-22
pubmed: 10690910
J Clin Oncol. 2010 May 10;28(14):2323-30
pubmed: 20368568
Thyroid. 2005 Jun;15(6):618-23
pubmed: 16029131
J Clin Endocrinol Metab. 2014 Sep;99(9):3055-9
pubmed: 24617713
Thyroid. 2017 Apr;27(4):587-590
pubmed: 28068878
Clin Oncol (R Coll Radiol). 2010 Aug;22(6):475-85
pubmed: 20627492
J Clin Endocrinol Metab. 2006 Feb;91(2):371-7
pubmed: 16303835
Thyroid. 2014 Jun;24(6):1062-6
pubmed: 24499195
Thyroid. 2015 Jun;25(6):567-610
pubmed: 25810047
J Natl Compr Canc Netw. 2010 May;8(5):549-56
pubmed: 20495084
J Clin Endocrinol Metab. 2006 Jul;91(7):2496-9
pubmed: 16608897