What we can learn from a genetic rodent model about autism.

Animals Autism Spectrum Disorder / genetics Behavior, Animal / physiology Disease Models, Animal Mice Models, Genetic Perception / physiology Rats Social Behavior Social Cognition Stereotyped Behavior / physiology
Animal model Autism spectrum disorder Behavioural testing Cntnap2 Fragile-X Genetic Mechanisms

Journal

Neuroscience and biobehavioral reviews
ISSN: 1873-7528
Titre abrégé: Neurosci Biobehav Rev
Pays: United States
ID NLM: 7806090

Informations de publication

Date de publication:
02 2020
Historique:
received: 05 09 2019
revised: 28 10 2019
accepted: 10 12 2019
pubmed: 31 12 2019
medline: 5 1 2021
entrez: 31 12 2019
Statut: ppublish

Résumé

Autism spectrum disorders (ASD) are complex neurodevelopmental disorders that are caused by genetic and/or environmental impacts, often probably by the interaction of both. They are characterised by deficits in social communication and interaction and by restricted and repetitive behaviours and interests from early childhood on, causing significant impairment. While it is clear that no animal model captures the full complexity of ASD in humans, genetic models are extremely useful for studying specific symptoms associated with ASD and the underlying cellular and molecular mechanisms. In this review we summarize the behavioral paradigms used in rodents to model ASD symptoms as they are listed in the DSM-5. We then review existing genetic rodent models with disruptions in ASD candidate genes, and we map their phenotypes onto these behavioural paradigms. The goal of this review is to give a comprehensive overview on how ASD symptoms can be studied in animal models and to give guidance for which animal models are appropriate to study specific symptom clusters.

Identifiants

DOI: 10.1016/j.neubiorev.2019.12.015 PMID: 31887338
pubmed: 31887338
pii: S0149-7634(19)30809-7
doi: 10.1016/j.neubiorev.2019.12.015
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

29-53

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Dorit Möhrle (D)

Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 3K7, Canada.

Marta Fernández (M)

Department of Pharmacology, School of Medicine, University of the Basque Country, Barrio Sarriena s/n, Leioa 48940, Spain.

Olga Peñagarikano (O)

Department of Pharmacology, School of Medicine, University of the Basque Country, Barrio Sarriena s/n, Leioa 48940, Spain; Centro de Investigación Biomédica en Red en Salud Mental, CIBERSAM, Spain.

Andreas Frick (A)

INSERM, Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U1215 Bordeaux, France; University of Bordeaux, Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, Bordeaux, France.

Brian Allman (B)

Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 3K7, Canada.

Susanne Schmid (S)

Department of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 3K7, Canada. Electronic address: Susanne.schmid@schulich.uwo.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › What we can learn from a genetic rodent model...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › What we can learn from a genetic rodent model...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement animal › What we can learn from a genetic rodent model...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › What we can learn from a genetic rodent model...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › What we can learn from a genetic rodent model...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles génétiques › What we can learn from a genetic rodent model...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Perception › What we can learn from a genetic rodent model...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › What we can learn from a genetic rodent model...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement social › What we can learn from a genetic rodent model...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Perception › Perception sociale › Cognition sociale › What we can learn from a genetic rodent model...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement stéréotypé › What we can learn from a genetic rodent model...