Gut Microbial, Inflammatory and Metabolic Signatures in Older People with Physical Frailty and Sarcopenia: Results from the BIOSPHERE Study.
aging
amino acids
biomarkers
gut microbiota
metabolism
multi-marker
muscle
physical performance
profiling
systemic inflammation
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
26 Dec 2019
26 Dec 2019
Historique:
received:
30
11
2019
revised:
19
12
2019
accepted:
23
12
2019
entrez:
1
1
2020
pubmed:
1
1
2020
medline:
4
9
2020
Statut:
epublish
Résumé
Physical frailty and sarcopenia (PF&S) share multisystem derangements, including variations in circulating amino acids and chronic low-grade inflammation. Gut microbiota balances inflammatory responses in several conditions and according to nutritional status. Therefore, an altered gut-muscle crosstalk has been hypothesized in PF&S. We analyzed the gut microbial taxa, systemic inflammation, and metabolic characteristics of older adults with and without PF&S. An innovative multi-marker analytical approach was applied to explore the classification performance of potential biomarkers for PF&S. Thirty-five community dwellers aged 70+, 18 with PF&S, and 17 nonPF&S controls were enrolled. Sequential and Orthogonalized Covariance Selection (SO-CovSel), a multi-platform regression method developed to handle highly correlated variables, was applied. The SO-CovSel model with the best prediction ability using the smallest number of variables was built using seven mediators. The model correctly classified 91.7% participants with PF&S and 87.5% nonPF&S controls. Compared with the latter group, PF&S participants showed higher serum concentrations of aspartic acid, lower circulating levels of concentrations of threonine and macrophage inflammatory protein 1α, increased abundance of
Identifiants
pubmed: 31887978
pii: nu12010065
doi: 10.3390/nu12010065
pmc: PMC7019826
pii:
doi:
Substances chimiques
Amino Acids
0
Cytokines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Innovative Medicines Initiative
ID : IMI-JU #115621
Organisme : Intramural Research Grants from the Università Cattolica del Sacro Cuore
ID : D3.2 2013
Organisme : Intramural Research Grants from the Università Cattolica del Sacro Cuore
ID : D3.2 2015
Organisme : Nonprofit research foundation "Centro Studi Achille e Linda Lorenzon"
ID : NA
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : CAPES; Finance Code 001
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