Long term osmotic stress exposure outcomes on rat dopaminergic innervations and the associated motor behavior.
Dopamine
Locomotion
Substantia nigra compacta
Ventral tegmental area
Water deprivation
Journal
Saudi journal of biological sciences
ISSN: 1319-562X
Titre abrégé: Saudi J Biol Sci
Pays: Saudi Arabia
ID NLM: 101543796
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
27
07
2018
revised:
29
07
2019
accepted:
01
08
2019
entrez:
1
1
2020
pubmed:
1
1
2020
medline:
1
1
2020
Statut:
ppublish
Résumé
The osmotic stress is a powerful stimulus that elicits profound peripheral and central disturbances. In the mammalian brain, osmotic stress has been associated to several glial and neuronal changes. The lack of data regarding the impact on the dopaminergic system and locomotion led us to investigate the effect of prolonged water deprivation in rat on the midbrain dopaminergic system and locomotor performance by dehydrating rats for one and two weeks. Locomotor activity and tyrosine hydroxylase (TH) expression were assessed using the open field test and immunohistochemistry respectively. Water deprivation was accompanied with a significant increment of TH expression within substantia nigra compacta (SNc) and ventral tegmental area (VTA) gradually as the duration of dehydration increases. While locomotor activity showed the inverse tendency manifested by a drop of crossed boxes number following one and two weeks of water deprivation. Our data suggest a substantial implication of midbrain dopaminergic system in the central response to the osmotic stimuli accompanied with locomotor deficiencies.
Identifiants
pubmed: 31889838
doi: 10.1016/j.sjbs.2019.08.003
pii: S1319-562X(19)30135-4
pmc: PMC6933151
doi:
Types de publication
Journal Article
Langues
eng
Pagination
210-213Informations de copyright
© 2019 Production and hosting by Elsevier B.V. on behalf of King Saud University.
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