R2TP/PAQosome as a promising chemotherapeutic target in cancer.
Cancer drugs
Chaperone
HNSCC
OSCC
PAQosome
R2TP
Journal
The Japanese dental science review
ISSN: 1882-7616
Titre abrégé: Jpn Dent Sci Rev
Pays: Netherlands
ID NLM: 101481371
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
27
06
2019
revised:
27
07
2019
accepted:
21
08
2019
entrez:
1
1
2020
pubmed:
1
1
2020
medline:
1
1
2020
Statut:
ppublish
Résumé
R2TP/PAQosome (particle for arrangement of quaternary structure) is a novel multisubunit chaperone specialized in the assembly/maturation of protein complexes that are involved in essential cellular processes such as PIKKs (phosphatidylinositol 3-kinase-like kinases) signaling, snoRNP (small nucleolar ribonucleoprotein) biogenesis, and RNAP II (RNA polymerase II) complex formation. In this review article, we describe the current understanding of R2TP/PAQosome functions and characteristics as well as how the chaperone complex is involved in oncogenesis, highlighting DNA damage response, mTOR (mammalian target of rapamycin) pathway as well as snoRNP biogenesis. Also, we discuss its possible involvement in HNSCC (head and neck squamous cell carcinoma) including OSCC (oral squamous cell carcinoma). Finally, we provide an overview of current anti-cancer drug development efforts targeting R2TP/PAQosome.
Identifiants
pubmed: 31890057
doi: 10.1016/j.jdsr.2019.08.001
pii: S1882-7616(19)30057-2
pmc: PMC6926247
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
38-42Informations de copyright
© 2019 The Authors.
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