Serum Tryptophan-Derived Quinolinate and Indole-3-Acetate Are Associated With Carotid Intima-Media Thickness and its Evolution in HIV-Infected Treated Adults.
HIV
antiretroviral
cardiovascular disease
carotid intima-media thickness
metabolomics
tryptophan metabolism
Journal
Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
25
10
2019
accepted:
05
12
2019
entrez:
1
1
2020
pubmed:
1
1
2020
medline:
1
1
2020
Statut:
epublish
Résumé
HIV-infected individuals undergoing effective antiretroviral therapy (ART) present an increased risk of atherosclerotic cardiovascular disease. We identified serum metabolites associated with carotid intima-media thickness (c-IMT) and its evolution. One hundred forty-three hydrophilic serum metabolites were measured by ultraperformance liquid chromatography coupled with high-resolution mass spectrometry in 49 HIV+ ART+, 48 HIV+ ART-naïve and 50 HIV-negative, age-matched, never-smoking male triads. Metabolites differentially altered between groups ("features") were defined as having a Benjamini-Hochberg-adjusted Compared with HIV-, metabolite features of HIV+ ART+ were increased N6,N6,N6-trimethyl-L-lysine and decreased ferulate and 5-hydroxy-L-tryptophan, whereas features of HIV+ ART-naïve were increased malate, kynurenine, 2-oxoglutarate, and indole-3-acetate and decreased succinate and 5-hydroxy-L-tryptophan. In HIV+ ART+ individuals, quinolinate and/or indole-3-acetate were positively associated with c-IMT ( In these highly selected HIV-positive ART-controlled males, 2 novel metabolites derived from tryptophan catabolism, indole-3-acetate and quinolinate, were associated with c-IMT and its progression.
Sections du résumé
BACKGROUND
BACKGROUND
HIV-infected individuals undergoing effective antiretroviral therapy (ART) present an increased risk of atherosclerotic cardiovascular disease. We identified serum metabolites associated with carotid intima-media thickness (c-IMT) and its evolution.
METHODS
METHODS
One hundred forty-three hydrophilic serum metabolites were measured by ultraperformance liquid chromatography coupled with high-resolution mass spectrometry in 49 HIV+ ART+, 48 HIV+ ART-naïve and 50 HIV-negative, age-matched, never-smoking male triads. Metabolites differentially altered between groups ("features") were defined as having a Benjamini-Hochberg-adjusted
RESULTS
RESULTS
Compared with HIV-, metabolite features of HIV+ ART+ were increased N6,N6,N6-trimethyl-L-lysine and decreased ferulate and 5-hydroxy-L-tryptophan, whereas features of HIV+ ART-naïve were increased malate, kynurenine, 2-oxoglutarate, and indole-3-acetate and decreased succinate and 5-hydroxy-L-tryptophan. In HIV+ ART+ individuals, quinolinate and/or indole-3-acetate were positively associated with c-IMT (
CONCLUSIONS
CONCLUSIONS
In these highly selected HIV-positive ART-controlled males, 2 novel metabolites derived from tryptophan catabolism, indole-3-acetate and quinolinate, were associated with c-IMT and its progression.
Identifiants
pubmed: 31890722
doi: 10.1093/ofid/ofz516
pii: ofz516
pmc: PMC6929253
doi:
Types de publication
Journal Article
Langues
eng
Pagination
ofz516Informations de copyright
© The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
Références
Curr HIV/AIDS Rep. 2016 Feb;13(1):44-52
pubmed: 26910597
Brief Bioinform. 2018 Nov 27;19(6):1356-1369
pubmed: 29106465
Atherosclerosis. 2009 Jun;204(2):561-6
pubmed: 19027117
Metabolomics. 2018 Mar;14(3):
pubmed: 30760970
AIDS. 2015 Jan 28;29(3):287-93
pubmed: 25686677
AIDS. 2018 Jul 31;32(12):1589-1598
pubmed: 29620717
Chem Sci. 2014 May 1;5(5):1765-1771
pubmed: 26682037
BMC Infect Dis. 2013 May 04;13:203
pubmed: 23641933
Nat Med. 2017 Feb;23(2):174-184
pubmed: 28092664
Sci Transl Med. 2013 Jul 10;5(193):193ra91
pubmed: 23843452
J Infect Dis. 2015 Aug 1;212(3):355-66
pubmed: 25616404
Arch Intern Med. 2010 Jul 26;170(14):1228-38
pubmed: 20660842
Clin Infect Dis. 2018 Jul 2;67(2):235-242
pubmed: 29415228
Lancet HIV. 2018 Jun;5(6):e291-e300
pubmed: 29731407
J Infect Dis. 2014 Aug 1;210(3):383-91
pubmed: 24585899
Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361
pubmed: 27899662
J Am Coll Cardiol. 2013 Feb 5;61(5):511-23
pubmed: 23369416
Atherosclerosis. 2016 Apr;247:64-9
pubmed: 26868510
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Gut. 2019 Jan;68(1):70-82
pubmed: 29899081
Clin Infect Dis. 2016 Jul 15;63(2):249-56
pubmed: 27118787
Sci Rep. 2018 Nov 16;8(1):16947
pubmed: 30446683
AIDS. 2006 Nov 28;20(18):2275-83
pubmed: 17117013
Clin Microbiol Rev. 2013 Jan;26(1):2-18
pubmed: 23297256
Eur Heart J. 2017 Oct 14;38(39):2948-2956
pubmed: 29020409
Curr Opin HIV AIDS. 2013 Mar;8(2):125-31
pubmed: 23380653
Cell Metab. 2014 Nov 4;20(5):799-812
pubmed: 25440057
Front Biosci (Landmark Ed). 2015 Jun 01;20:1116-43
pubmed: 25961549
J Acquir Immune Defic Syndr. 2015 Nov 1;70(3):228-35
pubmed: 26470032
Sci Rep. 2018 Apr 30;8(1):6725
pubmed: 29712976
J Am Soc Nephrol. 2015 Apr;26(4):876-87
pubmed: 25145928
PLoS One. 2016 Dec 12;11(12):e0161920
pubmed: 27941971
Mol Biosyst. 2013 Jan 27;9(1):18-28
pubmed: 23114495
J Infect Dis. 2016 Feb 1;213(3):370-8
pubmed: 26347573
AIDS. 2013 Oct 23;27(16):2603-14
pubmed: 24100713
Metabolites. 2012 Oct 18;2(4):775-95
pubmed: 24957762
AIDS. 2015 Feb 20;29(4):443-52
pubmed: 25565500