Low-Dose Busulfan Reduces Human CD34
busulfan
c-kit
erythropoiesis
gene therapy
hematopoietic stem cell transplantation
immunodeficient mice
xenograft transplantation
Journal
Molecular therapy. Methods & clinical development
ISSN: 2329-0501
Titre abrégé: Mol Ther Methods Clin Dev
Pays: United States
ID NLM: 101624857
Informations de publication
Date de publication:
13 Dec 2019
13 Dec 2019
Historique:
received:
06
08
2019
accepted:
30
10
2019
entrez:
1
1
2020
pubmed:
1
1
2020
medline:
1
1
2020
Statut:
epublish
Résumé
Humanized animal models are central to efforts aimed at improving hematopoietic stem cell (HSC) transplantation with or without genetic modification. Human cell engraftment is feasible in immunodeficient mice; however, high HSC doses and conditioning limit broad use of xenograft models. We assessed human CD45
Identifiants
pubmed: 31890735
doi: 10.1016/j.omtm.2019.10.017
pii: S2329-0501(19)30125-1
pmc: PMC6909187
doi:
Types de publication
Journal Article
Langues
eng
Pagination
430-437Références
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