Bone quality in fluoride-exposed populations: A novel application of the ultrasonic method.
BMI, Body Mass Index
Bone biomarker
Bone quality
Ethiopian Rift Valley
F-, qFluoride
Fluoride exposure
IRB, Institutional Review Board
ISE, Ion Selective Electrode
MER, Main Ethiopian Rift
NOAEL, No-Observed-Adverse-Effects-Level
Quantitative ultrasound
SOS, Speed of Sound
Speed of sound
TISAB, Total Ionic Strength Adjuster Buffer
U.S. EPA, U.S. Environmental Protection Agency
U.S. NRC, U.S. National Research Institute
WHO, World Health Organization
bw, body weight
mg/L, milligram per liter
mg/kg bw/day, milligram per kilogram body weight per day
Journal
Bone reports
ISSN: 2352-1872
Titre abrégé: Bone Rep
Pays: United States
ID NLM: 101646176
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
15
11
2019
revised:
04
12
2019
accepted:
05
12
2019
entrez:
1
1
2020
pubmed:
1
1
2020
medline:
1
1
2020
Statut:
epublish
Résumé
Various studies, mostly with animals, have provided evidence of adverse impacts of fluoride (F In this observational study, we assessed variation in an integrated measures of bone quality in a population exposed to wide-ranging F We collected 871 speed of sound (SOS) measurements from 341 subjects residing in 25 communities, aged 10-70 years (188 males and 153 females). All subjects received scans of the cortical radius and tibia, and adults over the age of 19 received an additional scan of the phalanx. Associations between F We found negative associations between F These results are indicative of a fluoride-induced deterioration of bone quality in humans, likely reflecting a combination of factors related to SOS: net bone loss, abnormal mineralization and collagen formation, or altered microarchitecture. The portable and low-cost ultrasound technique appears potentially useful for assessment of bone quality, and should be tested in other locations and for other bone-related disorders, to assess the feasibility of its more extensive diagnostic use in hard-to-reach rural regions.
Sections du résumé
BACKGROUND
BACKGROUND
Various studies, mostly with animals, have provided evidence of adverse impacts of fluoride (F
OBJECTIVE
OBJECTIVE
In this observational study, we assessed variation in an integrated measures of bone quality in a population exposed to wide-ranging F
METHOD
METHODS
We collected 871 speed of sound (SOS) measurements from 341 subjects residing in 25 communities, aged 10-70 years (188 males and 153 females). All subjects received scans of the cortical radius and tibia, and adults over the age of 19 received an additional scan of the phalanx. Associations between F
RESULTS
RESULTS
We found negative associations between F
CONCLUSIONS
CONCLUSIONS
These results are indicative of a fluoride-induced deterioration of bone quality in humans, likely reflecting a combination of factors related to SOS: net bone loss, abnormal mineralization and collagen formation, or altered microarchitecture. The portable and low-cost ultrasound technique appears potentially useful for assessment of bone quality, and should be tested in other locations and for other bone-related disorders, to assess the feasibility of its more extensive diagnostic use in hard-to-reach rural regions.
Identifiants
pubmed: 31890757
doi: 10.1016/j.bonr.2019.100235
pii: S2352-1872(19)30041-5
pii: 100235
pmc: PMC6933268
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100235Subventions
Organisme : NIEHS NIH HHS
ID : R00 ES023472
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104940
Pays : United States
Informations de copyright
© 2019 The Authors.
Déclaration de conflit d'intérêts
The authors declare they have no actual or potential competing financial interests.
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