Telomere length associations with cognition depend on Alzheimer's disease biomarkers.
APOE
CSF biomarkers
Cognition
Executive function
Telomeres
Journal
Alzheimer's & dementia (New York, N. Y.)
ISSN: 2352-8737
Titre abrégé: Alzheimers Dement (N Y)
Pays: United States
ID NLM: 101650118
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
1
1
2020
pubmed:
1
1
2020
medline:
1
1
2020
Statut:
epublish
Résumé
While telomere shortening, a marker of cellular aging, may impact the progression of age-related neurodegenerative diseases, its association with cognition is unclear, particularly in the context of Alzheimer's disease (AD) pathology. Telomere, cognitive, and CSF data from 482 participants in the AD Neuroimaging Initiative (148 cognitively normal, 283 mild cognitive impairment, 51 AD) was leveraged to assess telomere length associations with cognition (measured by memory and executive function) and interactions with CSF amyloid-β, tau, and Longer telomeres at baseline were associated with faster executive function decline. Amyloid-β and tau interacted with telomere length on cognition, with longer telomeres related to faster decline among biomarker-positive individuals. Telomere associations with cognition shift with AD progression, with longer telomeres related to worse outcomes as pathology increases, highlighting the need for further investigation of telomere length along the AD neuropathological cascade.
Identifiants
pubmed: 31890852
doi: 10.1016/j.trci.2019.11.003
pii: S2352-8737(19)30089-7
pmc: PMC6926345
doi:
Types de publication
Journal Article
Langues
eng
Pagination
883-890Subventions
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG059941
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059716
Pays : United States
Organisme : NIH HHS
ID : S10 OD023680
Pays : United States
Organisme : NIA NIH HHS
ID : K01 AG049164
Pays : United States
Informations de copyright
© 2019 The Authors.
Références
Ann Neurol. 2006 Aug;60(2):174-80
pubmed: 16685698
Front Aging Neurosci. 2014 Aug 04;6:183
pubmed: 25140149
Ann Clin Lab Sci. 2016 May;46(3):260-5
pubmed: 27312549
Mech Ageing Dev. 2008 Apr;129(4):183-90
pubmed: 18242664
Hypertension. 2001 Feb;37(2 Pt 2):381-5
pubmed: 11230304
Neurosci Lett. 2011 Mar 29;492(1):15-8
pubmed: 21295115
Neurology. 1997 Sep;49(3):786-94
pubmed: 9305341
Neurobiol Aging. 2017 Oct;58:120-128
pubmed: 28732249
J Neurosci. 2015 Jan 28;35(4):1659-74
pubmed: 25632141
Exp Gerontol. 2012 Feb;47(2):179-82
pubmed: 22210159
Age Ageing. 2014 Mar;43(2):212-7
pubmed: 24231584
Nat Rev Neurosci. 2007 Jul;8(7):499-509
pubmed: 17551515
Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):245-52
pubmed: 21106948
J Gerontol A Biol Sci Med Sci. 2012 Apr;67(4):330-5
pubmed: 22016362
Brain Imaging Behav. 2012 Dec;6(4):502-16
pubmed: 22782295
PLoS One. 2011;6(7):e22521
pubmed: 21818333
Neuroimage. 2013 Feb 1;66:449-56
pubmed: 23103689
Neurobiol Aging. 2012 Feb;33(2):335-44
pubmed: 20395015
Ann Neurol. 2009 Apr;65(4):403-13
pubmed: 19296504
Nature. 1991 Apr 18;350(6319):569-73
pubmed: 1708110
Ann Transl Med. 2018 May;6(10):177
pubmed: 29951499
J Immunol. 1998 Jun 15;160(12):5702-6
pubmed: 9637478
J Neurochem. 2000 Jul;75(1):117-24
pubmed: 10854254
Neurobiol Aging. 2011 Nov;32(11):2055-60
pubmed: 20031273
Brain. 2011 Jul;134(Pt 7):2044-56
pubmed: 21672962
Mech Ageing Dev. 2014 Nov-Dec;141-142:64-9
pubmed: 25454987
J Magn Reson Imaging. 2008 Apr;27(4):685-91
pubmed: 18302232
Alzheimers Dement. 2014 Nov;10(6):637-645.e1
pubmed: 24656848
Neurobiol Aging. 2003 Jan-Feb;24(1):77-84
pubmed: 12493553
J Gerontol A Biol Sci Med Sci. 2016 Aug;71(8):1069-73
pubmed: 27091133
J Exp Med. 1996 Jun 1;183(6):2471-9
pubmed: 8676067
Brain Imaging Behav. 2012 Dec;6(4):517-27
pubmed: 22644789
JAMA Neurol. 2018 Aug 1;75(8):989-998
pubmed: 29801024
EBioMedicine. 2017 Jul;21:14-20
pubmed: 28347656
Am J Epidemiol. 2008 Apr 1;167(7):799-806
pubmed: 18270372
Neurology. 2009 Oct 13;73(15):1193-9
pubmed: 19822868
Mol Nutr Food Res. 2008 Jan;52(1):131-45
pubmed: 18203129
Alzheimers Dement. 2009 Nov;5(6):463-9
pubmed: 19896585
J Am Chem Soc. 2015 Jan 28;137(3):1213-9
pubmed: 25564872
Alzheimers Dement. 2006 Jul;2(3):164-8
pubmed: 19595878
Arch Neurol. 2012 Oct;69(10):1332-9
pubmed: 22825311
JAMA Neurol. 2014 Jul 1;71(7):921-3
pubmed: 25023551
Biol Res Nurs. 2012 Apr;14(2):124-32
pubmed: 21586494
BMC Geriatr. 2010 Sep 16;10:62
pubmed: 20843367
JAMA Neurol. 2014 Oct;71(10):1247-54
pubmed: 25090243
Neuromolecular Med. 2013 Mar;15(1):25-48
pubmed: 23161153
J Nutr Biochem. 2011 Oct;22(10):895-901
pubmed: 21429730
J Alzheimers Dis. 2019;71(1):33-43
pubmed: 31322561
Neurology. 2016 Aug 2;87(5):539-47
pubmed: 27371494
Neurobiol Aging. 2010 Apr;31(4):719-20
pubmed: 18599157