Radiation exposure alters airway deformability and bony structure displacement during laryngoscopy.
Airway
cancer
deformation
modeling
radiation therapy
Journal
Laryngoscope investigative otolaryngology
ISSN: 2378-8038
Titre abrégé: Laryngoscope Investig Otolaryngol
Pays: United States
ID NLM: 101684963
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
30
04
2019
revised:
23
07
2019
accepted:
20
08
2019
entrez:
1
1
2020
pubmed:
1
1
2020
medline:
1
1
2020
Statut:
epublish
Résumé
Prior therapeutic radiation exposure in the setting of head and neck malignancies is associated with difficult airway instrumentation. We sought to characterize the anatomic changes that produce this phenotype. Retrospective review. Five individuals with prior radiation therapy to the upper aerodigestive tract (previously irradiated) and 10 with no prior history of therapeutic radiation exposure (nonirradiated) were enrolled. Computed tomography images obtained before and during laryngoscope insertion ("uninstrumented" and "instrumented", respectively) were used to reconstruct three-dimensional representations of the pharyngeal airway, hyoid, and mandible. In the instrumented state, pharyngeal airway volumes were significantly greater in nonirradiated subjects relative to previously irradiated subjects ( Individuals with prior therapeutic radiation exposure to the upper aerodigestive tract differ from nonirradiated subjects with respect to airway deformation and bony structure translation during laryngoscopy. 4.
Sections du résumé
BACKGROUND
BACKGROUND
Prior therapeutic radiation exposure in the setting of head and neck malignancies is associated with difficult airway instrumentation. We sought to characterize the anatomic changes that produce this phenotype.
STUDY DESIGN
METHODS
Retrospective review.
METHODS
METHODS
Five individuals with prior radiation therapy to the upper aerodigestive tract (previously irradiated) and 10 with no prior history of therapeutic radiation exposure (nonirradiated) were enrolled. Computed tomography images obtained before and during laryngoscope insertion ("uninstrumented" and "instrumented", respectively) were used to reconstruct three-dimensional representations of the pharyngeal airway, hyoid, and mandible.
RESULTS
RESULTS
In the instrumented state, pharyngeal airway volumes were significantly greater in nonirradiated subjects relative to previously irradiated subjects (
CONCLUSION
CONCLUSIONS
Individuals with prior therapeutic radiation exposure to the upper aerodigestive tract differ from nonirradiated subjects with respect to airway deformation and bony structure translation during laryngoscopy.
LEVEL OF EVIDENCE
METHODS
4.
Identifiants
pubmed: 31890878
doi: 10.1002/lio2.311
pii: LIO2311
pmc: PMC6929586
doi:
Types de publication
Journal Article
Langues
eng
Pagination
609-616Subventions
Organisme : NCATS NIH HHS
ID : L30 TR001096
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA023108
Pays : United States
Informations de copyright
© 2019 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals, Inc. on behalf of The Triological Society.
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