Elevated Microparticle Tissue Factor Activity Differentiates Patients With Venous Thromboembolism in Anti-neutrophil Cytoplasmic Autoantibody Vasculitis.
autoimmunity
biomarkers
plasminogen
thrombosis
tissue factor
venous thrombosis
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
28
09
2018
revised:
18
06
2019
accepted:
08
07
2019
entrez:
1
1
2020
pubmed:
1
1
2020
medline:
1
1
2020
Statut:
epublish
Résumé
Venous thromboembolism (VTE) is a life-threatening complication of anti-neutrophil cytoplasmic autoantibody (ANCA) vasculitis whose mechanism remains incompletely elucidated. We tested the hypothesis that elevated microparticle tissue factor activity (MPTFa) or anti-plasminogen antibodies (anti-Plg) may identify patients at risk for VTE. In this prospective study, patients were enrolled during active disease and followed longitudinally. Twelve patients who experienced a VTE (VTE VTE Elevated MPTFa and increased anti-Plg in remission are strong indicators of VTE independent of renal function. Association of anti-Plg during remission with VTE implies hypercoagulability even during disease quiescence. Hypoalbuminemia strongly portends VTE risk, which is a novel finding in ANCA vasculitis. A thrombotic signature would allow improved management of patients to minimize VTE risk and complications of anticoagulation.
Identifiants
pubmed: 31891003
doi: 10.1016/j.ekir.2019.07.006
pii: S2468-0249(19)31408-1
pmc: PMC6933462
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1617-1629Subventions
Organisme : NHLBI NIH HHS
ID : K12 HL087097
Pays : United States
Organisme : NIDDK NIH HHS
ID : P01 DK058335
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016086
Pays : United States
Organisme : NIDDK NIH HHS
ID : U54 DK083912
Pays : United States
Informations de copyright
© 2019 International Society of Nephrology. Published by Elsevier Inc.
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