Xanthophyll β-Cryptoxanthin Inhibits Highly Refined Carbohydrate Diet-Promoted Hepatocellular Carcinoma Progression in Mice.
Animals
Apoptosis
/ drug effects
Beta-Cryptoxanthin
/ pharmacology
Body Weight
/ drug effects
Carcinoma, Hepatocellular
/ drug therapy
Dietary Carbohydrates
/ adverse effects
Dietary Supplements
Dioxygenases
/ genetics
Diterpenes
/ analysis
Glucose
/ metabolism
Glycolysis
/ drug effects
Hypoxia-Inducible Factor 1, alpha Subunit
/ metabolism
Liver Neoplasms
/ drug therapy
Male
Mice, Inbred C57BL
Mice, Knockout
Retinyl Esters
/ analysis
Tumor Hypoxia
/ drug effects
Tumor Microenvironment
/ drug effects
Tumor Suppressor Protein p53
/ metabolism
Vitamin A
/ analysis
beta-Carotene 15,15'-Monooxygenase
/ genetics
carotenoid cleavage enzymes
glucose metabolism
hepatocellular carcinoma
highly refined carbohydrate diets
β-Cryptoxanthin
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
06
09
2019
revised:
21
11
2019
pubmed:
1
1
2020
medline:
15
12
2020
entrez:
1
1
2020
Statut:
ppublish
Résumé
β-Cryptoxanthin (BCX) can be cleaved by both β-carotene 15,15'-oxygenase (BCO1) and β-carotene 9',10'-oxygenase (BCO2), generating biological active vitamin A and apocarotenoids. We examined whether BCX feeding could inhibit diethylnitrosamine (DEN)-initiated, highly refined carbohydrate diet (HRCD)-promoted hepatocellular carcinoma (HCC) development, dependent or independent of BCO1/BCO2 activity. Two-week-old male wild-type (WT) and BCO1 This study suggests that BCX feeding may alleviate HRCD-promoted HCC progression by modulating the acetylation of p53, hypoxic tumor microenvironment, and glucose metabolism, independent of BCO1/BCO2.
Identifiants
pubmed: 31891208
doi: 10.1002/mnfr.201900949
doi:
Substances chimiques
Beta-Cryptoxanthin
0
Dietary Carbohydrates
0
Diterpenes
0
Hif1a protein, mouse
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
Retinyl Esters
0
Trp53 protein, mouse
0
Tumor Suppressor Protein p53
0
Vitamin A
11103-57-4
retinol palmitate
1D1K0N0VVC
Dioxygenases
EC 1.13.11.-
Bco1 protein, mouse
EC 1.13.11.63
Bco2 protein, mouse
EC 1.14.99.-
beta-Carotene 15,15'-Monooxygenase
EC 1.14.99.36
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900949Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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